Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1805380..1805560 Replicon chromosome
Accession NZ_CP021105
Organism Staphylococcus aureus strain CC5

Toxin (Protein)


Gene name sprA1 Uniprot ID Q8VVS0
Locus tag B4893_RS08980 Protein ID WP_001791613.1
Coordinates 1805380..1805472 (+) Length 31 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1805503..1805560 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4893_RS08950 1800543..1801193 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
B4893_RS08955 1801274..1802269 + 996 WP_000070642.1 DUF4352 domain-containing protein -
B4893_RS08960 1802344..1802970 + 627 WP_000669024.1 hypothetical protein -
B4893_RS08965 1803011..1803352 + 342 WP_000627540.1 DUF3969 family protein -
B4893_RS08970 1803453..1804025 + 573 WP_000414216.1 hypothetical protein -
B4893_RS08975 1804223..1805235 - 1013 Protein_1679 IS3 family transposase -
B4893_RS08980 1805380..1805472 + 93 WP_001791613.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1805503..1805560 - 58 - - Antitoxin
B4893_RS08985 1805598..1805699 + 102 WP_001792025.1 hypothetical protein -
B4893_RS08990 1805677..1805838 - 162 Protein_1682 transposase -
B4893_RS08995 1805829..1806323 - 495 Protein_1683 transposase -
B4893_RS09000 1806775..1808004 - 1230 WP_000072627.1 restriction endonuclease subunit S -
B4893_RS09005 1807997..1809553 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
B4893_RS09010 1809717..1809851 - 135 WP_001791797.1 hypothetical protein -
B4893_RS09015 1809914..1810389 - 476 Protein_1687 serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1800579..1840970 40391


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 31 a.a.        Molecular weight: 3471.23 Da        Isoelectric Point: 9.7333

>T75971 WP_001791613.1 NZ_CP021105:1805380-1805472 [Staphylococcus aureus]
MLIIFVHIIAPVISGCAVAYYTYWLSKRNK

Download         Length: 93 bp

>T75971 NZ_CP021105:1805380-1805472 [Staphylococcus aureus]
TTGCTAATCATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCTGTTGCGTATTATACTTATTGGCTTAGTAA
ACGCAACAAATAA

Antitoxin


Download         Length: 58 bp

>AT75971 NZ_CP021105:c1805560-1805503 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8VVS0

Antitoxin

Download structure file

References