Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1930805..1930987 Replicon chromosome
Accession NZ_CP020619
Organism Staphylococcus aureus strain JE2

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag B7H15_RS15365 Protein ID WP_001801861.1
Coordinates 1930805..1930900 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1930928..1930987 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7H15_RS09800 1926465..1927091 + 627 Protein_1835 hypothetical protein -
B7H15_RS09805 1927132..1927476 + 345 WP_000627551.1 DUF3969 family protein -
B7H15_RS09810 1927574..1928125 + 552 WP_000414205.1 hypothetical protein -
B7H15_RS09815 1928343..1928984 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
B7H15_RS09820 1929098..1929283 - 186 WP_000809857.1 hypothetical protein -
B7H15_RS09825 1929285..1929461 - 177 WP_000375476.1 hypothetical protein -
B7H15_RS09830 1929472..1929855 - 384 WP_000070811.1 hypothetical protein -
B7H15_RS09840 1930459..1930602 - 144 WP_001549059.1 transposase -
B7H15_RS15365 1930805..1930900 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1930928..1930987 - 60 - - Antitoxin
B7H15_RS09845 1931023..1931124 + 102 WP_001791893.1 hypothetical protein -
B7H15_RS09850 1931102..1931278 - 177 Protein_1845 transposase -
B7H15_RS09855 1931472..1931849 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1923905..1964076 40171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T75189 WP_001801861.1 NZ_CP020619:1930805-1930900 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T75189 NZ_CP020619:1930805-1930900 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT75189 NZ_CP020619:c1930987-1930928 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References