Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 3538762..3538971 Replicon chromosome
Accession NZ_CP020424
Organism Clostridioides difficile strain FDAARGOS_267

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag A6J95_RS16525 Protein ID WP_004454815.1
Coordinates 3538762..3538920 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 3538837..3538971 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J95_RS16495 3534558..3535226 + 669 WP_009897711.1 VanZ family protein -
A6J95_RS16500 3535266..3535346 + 81 Protein_3103 VOC family protein -
A6J95_RS16505 3535709..3535981 - 273 WP_004454820.1 tyrosine-type recombinase/integrase -
A6J95_RS16510 3536212..3536633 - 422 Protein_3105 hypothetical protein -
A6J95_RS16515 3536652..3536750 - 99 Protein_3106 Arm DNA-binding domain-containing protein -
A6J95_RS16520 3537033..3538403 + 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
A6J95_RS16525 3538762..3538920 + 159 WP_004454815.1 hypothetical protein Toxin
- 3538837..3538971 - 135 NuclAT_0 - Antitoxin
A6J95_RS16530 3540232..3540615 + 384 Protein_3109 BlaI/MecI/CopY family transcriptional regulator -
A6J95_RS16535 3540804..3541799 - 996 WP_003431031.1 asparaginase -
A6J95_RS16540 3541920..3543548 - 1629 WP_009897704.1 aspartate 4-decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T74672 WP_004454815.1 NZ_CP020424:3538762-3538920 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T74672 NZ_CP020424:3538762-3538920 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT74672 NZ_CP020424:c3538971-3538837 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References