Detailed information of TA system TA074488

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3831834..3832043
• Replicon: chromosome
• Accession: NZ_CP020380
• Organism: Clostridioides difficile strain DSM 102978

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: CDIF102978_RS18320
• Protein ID: WP_021376576.1
• Coordinates: 3831885..3832043 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	3831834..3831968 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF102978_RS18290	3827109..3828071	-	963	WP_077709036.1	XkdQ	-
CDIF102978_RS18295	3828068..3828739	-	672	WP_021374971.1	LysM peptidoglycan-binding domain-containing protein	-
CDIF102978_RS18300	3829079..3829237	-	159	WP_021374929.1	hypothetical protein	-
CDIF102978_RS18305	3829412..3829615	-	204	WP_021374945.1	hypothetical protein	-
CDIF102978_RS18310	3829675..3830493	-	819	WP_045146391.1	toxin Bro	-
CDIF102978_RS18315	3830619..3830795	-	177	WP_021360954.1	ribbon-helix-helix protein, CopG family	-
-	3831834..3831968	+	135	NuclAT_0	-	Antitoxin
CDIF102978_RS18320	3831885..3832043	-	159	WP_021376576.1	hypothetical protein	Toxin
CDIF102978_RS18325	3832262..3832663	+	402	WP_021376513.1	type II toxin-antitoxin system HicB family antitoxin	-
CDIF102978_RS18330	3832732..3833851	+	1120	Protein_3479	site-specific integrase	-
CDIF102978_RS18335	3834002..3834682	-	681	WP_065977729.1	response regulator transcription factor	-
CDIF102978_RS18340	3834732..3836747	-	2016	WP_045146397.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5968.19 Da
• Isoelectric Point: 11.1660

>T74488 WP_021376576.1 NZ_CP020380:c3832043-3831885 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIKFHKTK

Nucleotide

• Length: 159 bp

>T74488 NZ_CP020380:c3832043-3831885 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAAATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT74488 NZ_CP020380:3831834-3831968 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATTTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin