Detailed information of TA system TA074485

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2895469..2895686
• Replicon: chromosome
• Accession: NZ_CP020380
• Organism: Clostridioides difficile strain DSM 102978

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: CDIF102978_RS14165
• Protein ID: WP_021375974.1
• Coordinates: 2895528..2895686 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	2895469..2895512 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF102978_RS14150	2891906..2893534	+	1629	WP_021376019.1	aspartate 4-decarboxylase	-
CDIF102978_RS14155	2893655..2894650	+	996	WP_021376103.1	asparaginase	-
CDIF102978_RS14160	2894812..2894982	-	171	WP_077708801.1	IS3 family transposase	-
-	2895469..2895512	+	44	NuclAT_4	-	Antitoxin
CDIF102978_RS14165	2895528..2895686	-	159	WP_021375974.1	hypothetical protein	Toxin
CDIF102978_RS14170	2896108..2898528	-	2421	WP_021376018.1	leucine--tRNA ligase	-
CDIF102978_RS14175	2898882..2899232	-	351	WP_003416416.1	ribosome silencing factor	-
CDIF102978_RS14180	2899349..2899921	-	573	WP_003431048.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
CDIF102978_RS14185	2899922..2900611	-	690	WP_118090923.1	nicotinate-nucleotide adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6026.23 Da
• Isoelectric Point: 11.3102

>T74485 WP_021375974.1 NZ_CP020380:c2895686-2895528 [Clostridioides difficile]
MDNFLQGILASLSASLIVYITSKLFGKRKKPLKAATKSGWEFDFKIKFRRFK

Nucleotide

• Length: 159 bp

>T74485 NZ_CP020380:c2895686-2895528 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATACTAGCGAGTCTATCTGCTAGTTTAATAGTCTATATAACTAGCAAGTTATTTGGAAA
ACGTAAAAAACCACTCAAAGCTGCAACTAAGAGTGGTTGGGAGTTTGATTTTAAAATCAAATTCCGTAGATTTAAATAA

Antitoxin

Nucleotide

• Length: 44 bp

>AT74485 NZ_CP020380:2895469-2895512 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGGAGTTCATAAT

Structures

Antitoxin