Detailed information of TA system TA074479

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3831836..3832045
• Replicon: chromosome
• Accession: NZ_CP020379
• Organism: Clostridioides difficile strain DSM 102860

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: CDIF102860_RS18320
• Protein ID: WP_021376576.1
• Coordinates: 3831887..3832045 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	3831836..3831970 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF102860_RS18290	3827111..3828073	-	963	WP_077709036.1	XkdQ	-
CDIF102860_RS18295	3828070..3828741	-	672	WP_021374971.1	LysM peptidoglycan-binding domain-containing protein	-
CDIF102860_RS18300	3829081..3829239	-	159	WP_021374929.1	hypothetical protein	-
CDIF102860_RS18305	3829414..3829617	-	204	WP_021374945.1	hypothetical protein	-
CDIF102860_RS18310	3829677..3830495	-	819	WP_045146391.1	toxin Bro	-
CDIF102860_RS18315	3830621..3830797	-	177	WP_021360954.1	ribbon-helix-helix protein, CopG family	-
-	3831836..3831970	+	135	NuclAT_0	-	Antitoxin
CDIF102860_RS18320	3831887..3832045	-	159	WP_021376576.1	hypothetical protein	Toxin
CDIF102860_RS18325	3832264..3832665	+	402	WP_021376513.1	type II toxin-antitoxin system HicB family antitoxin	-
CDIF102860_RS18330	3832734..3833853	+	1120	Protein_3479	site-specific integrase	-
CDIF102860_RS18335	3834004..3834684	-	681	WP_065977729.1	response regulator transcription factor	-
CDIF102860_RS18340	3834734..3836749	-	2016	WP_045146397.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5968.19 Da
• Isoelectric Point: 11.1660

>T74479 WP_021376576.1 NZ_CP020379:c3832045-3831887 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIKFHKTK

Nucleotide

• Length: 159 bp

>T74479 NZ_CP020379:c3832045-3831887 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAAATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT74479 NZ_CP020379:3831836-3831970 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATTTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin