Detailed information of TA system TA074470

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3825066..3825275
• Replicon: chromosome
• Accession: NZ_CP020378
• Organism: Clostridioides difficile strain DSM 102859

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: CDIF102859_RS18215
• Protein ID: WP_021376576.1
• Coordinates: 3825117..3825275 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	3825066..3825200 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF102859_RS18185	3820341..3821303	-	963	WP_077709036.1	XkdQ	-
CDIF102859_RS18190	3821300..3821971	-	672	WP_021374971.1	LysM peptidoglycan-binding domain-containing protein	-
CDIF102859_RS18195	3822311..3822469	-	159	WP_021374929.1	hypothetical protein	-
CDIF102859_RS18200	3822644..3822847	-	204	WP_021374945.1	hypothetical protein	-
CDIF102859_RS18205	3822907..3823725	-	819	WP_045146391.1	toxin Bro	-
CDIF102859_RS18210	3823851..3824027	-	177	WP_021360954.1	ribbon-helix-helix protein, CopG family	-
-	3825066..3825200	+	135	NuclAT_0	-	Antitoxin
CDIF102859_RS18215	3825117..3825275	-	159	WP_021376576.1	hypothetical protein	Toxin
CDIF102859_RS18220	3825494..3825895	+	402	WP_021376513.1	type II toxin-antitoxin system HicB family antitoxin	-
CDIF102859_RS18225	3825964..3827083	+	1120	Protein_3457	site-specific integrase	-
CDIF102859_RS18230	3827234..3827914	-	681	WP_065977729.1	response regulator transcription factor	-
CDIF102859_RS18235	3827964..3829979	-	2016	WP_045146397.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5968.19 Da
• Isoelectric Point: 11.1660

>T74470 WP_021376576.1 NZ_CP020378:c3825275-3825117 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIKFHKTK

Nucleotide

• Length: 159 bp

>T74470 NZ_CP020378:c3825275-3825117 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAAATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT74470 NZ_CP020378:3825066-3825200 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATTTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin