Detailed information of TA system TA073650

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 750121..750324
• Replicon: chromosome
• Accession: NZ_CP019986
• Organism: Citrobacter werkmanii strain BF-6

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: B2G73_RS03590
• Protein ID: WP_042307991.1
• Coordinates: 750121..750324 (+)
• Length: 68 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	750228..750314 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B2G73_RS03560	745527..747215	-	1689	WP_079223641.1	iron ABC transporter permease	-
B2G73_RS03565	747199..748236	-	1038	WP_079223644.1	extracellular solute-binding protein	-
B2G73_RS03570	748593..748898	-	306	WP_061381963.1	hypothetical protein	-
B2G73_RS25585	748902..749063	+	162	WP_154050537.1	hypothetical protein	-
B2G73_RS03575	749169..749423	-	255	WP_042307639.1	hypothetical protein	-
B2G73_RS25905	749623..749907	-	285	WP_208616120.1	hypothetical protein	-
B2G73_RS03590	750121..750324	+	204	WP_042307991.1	SymE family type I addiction module toxin	Toxin
-	750228..750314	-	87	-	-	Antitoxin
B2G73_RS03595	750618..751001	-	384	WP_208616116.1	hypothetical protein	-
B2G73_RS03600	751203..751523	-	321	WP_042307641.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-35)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7599.68 Da
• Isoelectric Point: 8.5047

>T73650 WP_042307991.1 NZ_CP019986:750121-750324 [Citrobacter werkmanii]
MTTYYSQHPSLTLKGDWLREAGFETGKGVTVKISEVDEVRELRKELYLMKKSMNHVKAGVNNVVNGD

Nucleotide

• Length: 204 bp

>T73650 NZ_CP019986:750121-750324 [Citrobacter werkmanii]
ATGACCACATATTACTCACAGCATCCCAGCCTGACCCTCAAGGGTGACTGGTTAAGAGAAGCGGGATTTGAGACAGGGAA
AGGCGTCACGGTGAAGATTTCGGAAGTGGACGAAGTGAGGGAGCTACGGAAGGAGCTTTATCTGATGAAAAAGTCGATGA
ATCATGTTAAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Nucleotide

• Length: 87 bp

>AT73650 NZ_CP019986:c750314-750228 [Citrobacter werkmanii]
TTCACCACATTATTTACCCCCGCCTTAACATGATTCATCGACTTTTTCATCAGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCC

Structures

Antitoxin