Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1256735..1256944 Replicon chromosome
Accession NZ_CP019870
Organism Clostridioides difficile strain BR81

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag BZ168_RS05365 Protein ID WP_004454815.1
Coordinates 1256735..1256893 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 1256810..1256944 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ168_RS05345 1252587..1253255 + 669 WP_021361938.1 VanZ family protein -
BZ168_RS18955 1253295..1253375 + 81 Protein_1050 VOC family protein -
BZ168_RS05355 1253738..1254855 - 1118 Protein_1051 site-specific integrase -
BZ168_RS05360 1255071..1256441 + 1371 WP_021373596.1 cell wall-binding protein Cwp29 -
BZ168_RS05365 1256735..1256893 + 159 WP_004454815.1 hypothetical protein Toxin
- 1256810..1256944 - 135 NuclAT_0 - Antitoxin
BZ168_RS05370 1258202..1258585 + 384 Protein_1054 BlaI/MecI/CopY family transcriptional regulator -
BZ168_RS05375 1258763..1259758 - 996 WP_003431031.1 asparaginase -
BZ168_RS05380 1259879..1261507 - 1629 WP_004454813.1 aspartate 4-decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T73393 WP_004454815.1 NZ_CP019870:1256735-1256893 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T73393 NZ_CP019870:1256735-1256893 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT73393 NZ_CP019870:c1256944-1256810 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References