73364

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2853988..2854197 Replicon chromosome
Accession NZ_CP019858
Organism Clostridioides difficile strain DSM 29688

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF29688_RS14125 Protein ID WP_004454815.1
Coordinates 2854039..2854197 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2853988..2854122 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29688_RS14110 2849426..2851054 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CDIF29688_RS14115 2851175..2852170 + 996 WP_003431031.1 asparaginase -
CDIF29688_RS14120 2852348..2852731 - 384 WP_021390236.1 BlaI/MecI/CopY family transcriptional regulator -
- 2853988..2854122 + 135 NuclAT_6 - Antitoxin
CDIF29688_RS14125 2854039..2854197 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF29688_RS14130 2854556..2855926 - 1371 WP_021390237.1 cell wall-binding protein Cwp29 -
CDIF29688_RS14135 2856140..2857258 + 1119 WP_021366970.1 site-specific integrase -
CDIF29688_RS14140 2857575..2858243 - 669 WP_021366877.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T73364 WP_004454815.1 NZ_CP019858:c2854197-2854039 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T73364 NZ_CP019858:c2854197-2854039 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT73364 NZ_CP019858:2853988-2854122 [Clostridioides difficile]
AAGAATAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References