Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1545452..1545648 Replicon chromosome
Accession NZ_CP019858
Organism Clostridioides difficile strain DSM 29688

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag CDIF29688_RS07765 Protein ID WP_009902496.1
Coordinates 1545452..1545604 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1545548..1545648 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29688_RS07735 1541029..1541622 - 594 WP_003438546.1 DUF308 domain-containing protein -
CDIF29688_RS07740 1541729..1542157 + 429 WP_021366451.1 DMT family transporter -
CDIF29688_RS07745 1542224..1542892 + 669 WP_003429358.1 diphthine--ammonia ligase -
CDIF29688_RS07750 1543010..1544365 - 1356 WP_003438549.1 MATE family efflux transporter -
CDIF29688_RS07765 1545452..1545604 + 153 WP_009902496.1 hypothetical protein Toxin
- 1545548..1545648 - 101 NuclAT_9 - Antitoxin
CDIF29688_RS07770 1546697..1548430 - 1734 WP_009902497.1 diguanylate cyclase -
CDIF29688_RS07775 1548670..1549515 - 846 WP_021366437.1 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-122)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T73354 WP_009902496.1 NZ_CP019858:1545452-1545604 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T73354 NZ_CP019858:1545452-1545604 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGCGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT73354 NZ_CP019858:c1545648-1545548 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCGCTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References