Detailed information of TA system TA073348

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1203398..1203613
• Replicon: chromosome
• Accession: NZ_CP019858
• Organism: Clostridioides difficile strain DSM 29688

Toxin (Protein)

• Gene name: CD2889
• Uniprot ID: Q183X5
• Locus tag: CDIF29688_RS06060
• Protein ID: WP_011861731.1
• Coordinates: 1203398..1203541 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1203463..1203613 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF29688_RS06035	1199055..1199417	+	363	WP_015984864.1	hypothetical protein	-
CDIF29688_RS06040	1199583..1200101	+	519	WP_009898407.1	hypothetical protein	-
CDIF29688_RS06045	1200165..1201751	-	1587	WP_015984865.1	hypothetical protein	-
CDIF29688_RS06050	1201727..1202248	-	522	WP_009898403.1	ImmA/IrrE family metallo-endopeptidase	-
CDIF29688_RS06055	1202950..1203138	-	189	WP_009898401.1	hypothetical protein	-
CDIF29688_RS06060	1203398..1203541	+	144	WP_011861731.1	hypothetical protein	Toxin
-	1203463..1203613	-	151	NuclAT_1	-	Antitoxin
-	1203467..1203613	-	147	NuclAT_0	-	-
CDIF29688_RS06065	1204048..1204425	+	378	WP_021391346.1	BlaI/MecI/CopY family transcriptional regulator	-
CDIF29688_RS06070	1204535..1204918	+	384	WP_015984867.1	BlaI/MecI/CopY family transcriptional regulator	-
CDIF29688_RS06075	1205103..1205687	+	585	Protein_1074	GntR family transcriptional regulator	-
CDIF29688_RS06080	1205713..1206126	+	414	WP_009896035.1	PTS sugar transporter subunit IIA	-
CDIF29688_RS06085	1206130..1206873	+	744	WP_003437997.1	membrane complex biogenesis protein, BtpA family	-
CDIF29688_RS06090	1206873..1207343	+	471	WP_003428544.1	PTS sugar transporter subunit IIB	-
CDIF29688_RS06095	1207360..1208118	+	759	WP_009888882.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1149271..1225633	76362

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5399.34 Da
• Isoelectric Point: 10.8277

>T73348 WP_011861731.1 NZ_CP019858:1203398-1203541 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH

Nucleotide

• Length: 144 bp

>T73348 NZ_CP019858:1203398-1203541 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA

Antitoxin

Nucleotide

• Length: 151 bp

>AT73348 NZ_CP019858:c1203613-1203463 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG

Structures

Toxin

• AlphaFold DB: A0A069A3R1

Antitoxin