Detailed information of TA system TA073344

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1183510..1183730
• Replicon: chromosome
• Accession: NZ_CP019858
• Organism: Clostridioides difficile strain DSM 29688

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: A0A069AVC0
• Locus tag: CDIF29688_RS20305
• Protein ID: WP_009901465.1
• Coordinates: 1183510..1183671 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1183591..1183730 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF29688_RS05885	1178622..1178855	+	234	WP_003429842.1	hypothetical protein	-
CDIF29688_RS05890	1178865..1179266	+	402	WP_015984842.1	hypothetical protein	-
CDIF29688_RS05895	1179260..1179607	+	348	WP_015984843.1	hypothetical protein	-
CDIF29688_RS05900	1179607..1180032	+	426	WP_009896626.1	HK97 gp10 family phage protein	-
CDIF29688_RS05905	1180025..1180462	+	438	WP_009901457.1	hypothetical protein	-
CDIF29688_RS05910	1180455..1180631	+	177	WP_021368348.1	hypothetical protein	-
CDIF29688_RS05915	1180632..1181942	+	1311	WP_015984844.1	phage tail sheath family protein	-
CDIF29688_RS05920	1181964..1182434	+	471	WP_015984845.1	phage tail tube protein	-
CDIF29688_RS05925	1182487..1182744	+	258	WP_015984846.1	hypothetical protein	-
CDIF29688_RS05930	1182749..1183189	+	441	WP_015984847.1	hypothetical protein	-
CDIF29688_RS20305	1183510..1183671	+	162	WP_009901465.1	hypothetical protein	Toxin
-	1183591..1183730	-	140	NuclAT_3	-	Antitoxin
-	1183591..1183730	-	140	NuclAT_5	-	Antitoxin
CDIF29688_RS05940	1183820..1184053	+	234	WP_015984848.1	hypothetical protein	-
CDIF29688_RS05945	1184113..1184640	+	528	WP_015984849.1	DUF4352 domain-containing protein	-
CDIF29688_RS05950	1184782..1185342	+	561	WP_015984850.1	hypothetical protein	-
CDIF29688_RS05955	1185420..1187708	+	2289	WP_015984851.1	tape measure protein	-
CDIF29688_RS05960	1187725..1188426	+	702	WP_015984852.1	LysM peptidoglycan-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1149271..1225633	76362

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6034.28 Da
• Isoelectric Point: 11.0253

>T73344 WP_009901465.1 NZ_CP019858:1183510-1183671 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELGFKIKFRKFK

Nucleotide

• Length: 162 bp

>T73344 NZ_CP019858:1183510-1183671 [Clostridioides difficile]
ATGGACAATTTTTTACTTAGTATATTAGCTAGCTTGATAGCTAGTTTAATTGGATATATCGTTTGTAGATGTATCAAAAA
CGTAAAAAGCCACTCTACTCGTGGCAAGAGTAAAAGTGGCTGGGAACTTGGTTTTAAAATAAAGTTCCGCAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT73344 NZ_CP019858:c1183730-1183591 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAAATATAAATTATTTAAATTTGCGGAACTT
TATTTTAAAACCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVC0

Antitoxin