Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1506340..1506549 Replicon chromosome
Accession NZ_CP019469
Organism Clostridioides difficile strain LEM1

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag BWD37_RS07170 Protein ID WP_004454815.1
Coordinates 1506340..1506498 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 1506415..1506549 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWD37_RS07150 (1502302) 1502302..1502970 + 669 WP_009897711.1 VanZ family protein -
BWD37_RS07155 (1503287) 1503287..1503559 - 273 WP_004454820.1 tyrosine-type recombinase/integrase -
BWD37_RS07160 (1504089) 1504089..1504280 - 192 Protein_1324 site-specific integrase -
BWD37_RS07165 (1504611) 1504611..1505981 + 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
BWD37_RS07170 (1506340) 1506340..1506498 + 159 WP_004454815.1 hypothetical protein Toxin
- (1506415) 1506415..1506549 - 135 NuclAT_1 - Antitoxin
- (1506415) 1506415..1506549 - 135 NuclAT_1 - Antitoxin
- (1506415) 1506415..1506549 - 135 NuclAT_2 - Antitoxin
BWD37_RS07175 (1507703) 1507703..1507987 + 285 WP_224213953.1 BlaI/MecI/CopY family transcriptional regulator -
BWD37_RS07180 (1508176) 1508176..1509171 - 996 WP_003431031.1 asparaginase -
BWD37_RS07185 (1509292) 1509292..1510920 - 1629 WP_004454813.1 aspartate 4-decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T72514 WP_004454815.1 NZ_CP019469:1506340-1506498 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T72514 NZ_CP019469:1506340-1506498 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT72514 NZ_CP019469:c1506549-1506415 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References