Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | CD-RCd/- |
Location | 1506340..1506549 | Replicon | chromosome |
Accession | NZ_CP019469 | ||
Organism | Clostridioides difficile strain LEM1 |
Toxin (Protein)
Gene name | CD2517.1 | Uniprot ID | Q182K5 |
Locus tag | BWD37_RS07170 | Protein ID | WP_004454815.1 |
Coordinates | 1506340..1506498 (+) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | RCd8 | ||
Locus tag | - | ||
Coordinates | 1506415..1506549 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BWD37_RS07150 (1502302) | 1502302..1502970 | + | 669 | WP_009897711.1 | VanZ family protein | - |
BWD37_RS07155 (1503287) | 1503287..1503559 | - | 273 | WP_004454820.1 | tyrosine-type recombinase/integrase | - |
BWD37_RS07160 (1504089) | 1504089..1504280 | - | 192 | Protein_1324 | site-specific integrase | - |
BWD37_RS07165 (1504611) | 1504611..1505981 | + | 1371 | WP_009897709.1 | cell wall-binding protein Cwp29 | - |
BWD37_RS07170 (1506340) | 1506340..1506498 | + | 159 | WP_004454815.1 | hypothetical protein | Toxin |
- (1506415) | 1506415..1506549 | - | 135 | NuclAT_1 | - | Antitoxin |
- (1506415) | 1506415..1506549 | - | 135 | NuclAT_1 | - | Antitoxin |
- (1506415) | 1506415..1506549 | - | 135 | NuclAT_2 | - | Antitoxin |
BWD37_RS07175 (1507703) | 1507703..1507987 | + | 285 | WP_224213953.1 | BlaI/MecI/CopY family transcriptional regulator | - |
BWD37_RS07180 (1508176) | 1508176..1509171 | - | 996 | WP_003431031.1 | asparaginase | - |
BWD37_RS07185 (1509292) | 1509292..1510920 | - | 1629 | WP_004454813.1 | aspartate 4-decarboxylase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 5996.20 Da Isoelectric Point: 11.3102
>T72514 WP_004454815.1 NZ_CP019469:1506340-1506498 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK
Download Length: 159 bp
>T72514 NZ_CP019469:1506340-1506498 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA
Antitoxin
Download Length: 135 bp
>AT72514 NZ_CP019469:c1506549-1506415 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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