Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3956382..3957181 Replicon chromosome
Accession NZ_CP018243
Organism Escherichia coli strain 350

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag BFL21_RS21830 Protein ID WP_000347273.1
Coordinates 3956717..3957181 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID C3ST72
Locus tag BFL21_RS21825 Protein ID WP_001302819.1
Coordinates 3956382..3956717 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL21_RS21810 3952167..3952937 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
BFL21_RS21815 3952953..3954287 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
BFL21_RS21820 3954662..3956233 + 1572 WP_001273776.1 galactarate dehydratase -
BFL21_RS21825 3956382..3956717 + 336 WP_001302819.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
BFL21_RS21830 3956717..3957181 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
BFL21_RS21835 3957236..3958045 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
BFL21_RS21845 3958294..3959574 + 1281 WP_000681927.1 tagatose-bisphosphate aldolase subunit KbaZ -
BFL21_RS21850 3959597..3960070 + 474 WP_001301475.1 PTS N-acetylgalactosamine transporter subunit IIB -
BFL21_RS21855 3960081..3960860 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
BFL21_RS21860 3960850..3961728 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
BFL21_RS21865 3961746..3962180 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3947741..3957181 9440


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T69123 WP_000347273.1 NZ_CP018243:3956717-3957181 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T69123 NZ_CP018243:3956717-3957181 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12388.97 Da        Isoelectric Point: 4.8616

>AT69123 WP_001302819.1 NZ_CP018243:3956382-3956717 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDTDIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT69123 NZ_CP018243:3956382-3956717 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SSH7


Antitoxin

Source ID Structure

References