66612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 2566843..2567068 Replicon chromosome
Accession NZ_CP017438
Organism Escherichia coli O157:H7 strain 2159

Toxin (Protein)


Gene name hokW Uniprot ID A0A1Q4PF16
Locus tag A4C45_RS13360 Protein ID WP_000813258.1
Coordinates 2566913..2567068 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2566843..2566901 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4C45_RS13310 2561908..2562150 + 243 WP_000747948.1 hypothetical protein -
A4C45_RS13315 2562134..2562559 + 426 WP_000693878.1 Rha family transcriptional regulator -
A4C45_RS31015 2562628..2563671 + 1044 WP_001262402.1 hypothetical protein -
A4C45_RS31020 2563664..2564125 + 462 WP_000139447.1 replication protein -
A4C45_RS13330 2564159..2564875 + 717 WP_000450627.1 DUF1627 domain-containing protein -
A4C45_RS13335 2564908..2565189 + 282 WP_000603384.1 DNA-binding protein -
A4C45_RS13340 2565186..2565413 + 228 WP_000699809.1 hypothetical protein -
A4C45_RS13345 2565406..2565717 + 312 WP_001289673.1 hypothetical protein -
A4C45_RS13350 2565845..2566063 + 219 WP_000683609.1 DUF4014 family protein -
A4C45_RS13355 2566065..2566622 + 558 WP_000104474.1 DUF551 domain-containing protein -
- 2566843..2566901 - 59 - - Antitoxin
A4C45_RS13360 2566913..2567068 + 156 WP_000813258.1 type I toxin-antitoxin system Hok family toxin Toxin
A4C45_RS13365 2567188..2567532 + 345 WP_000756596.1 YgiW/YdeI family stress tolerance OB fold protein -
A4C45_RS13370 2567654..2567926 + 273 WP_000191872.1 hypothetical protein -
A4C45_RS13375 2567928..2568977 + 1050 WP_001265229.1 DUF968 domain-containing protein -
A4C45_RS13380 2568990..2569295 + 306 WP_001217444.1 RusA family crossover junction endodeoxyribonuclease -
A4C45_RS13385 2569358..2569912 + 555 WP_000640035.1 DUF1133 family protein -
A4C45_RS31025 2570137..2570334 + 198 WP_000917763.1 hypothetical protein -
A4C45_RS13395 2570470..2571183 + 714 WP_000301797.1 helix-turn-helix domain-containing protein -
A4C45_RS13410 2571638..2572066 + 429 WP_001303509.1 tellurite resistance protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 2506365..2605476 99111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-47)


Sequences


Toxin        


Download         Length: 52 a.a.        Molecular weight: 5767.95 Da        Isoelectric Point: 7.7942

>T66612 WP_000813258.1 NZ_CP017438:2566913-2567068 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Download         Length: 156 bp

>T66612 NZ_CP017438:2566913-2567068 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 59 bp

>AT66612 NZ_CP017438:c2566901-2566843 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1Q4PF16


Antitoxin

Download structure file

References