Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 2566843..2567068 | Replicon | chromosome |
Accession | NZ_CP017438 | ||
Organism | Escherichia coli O157:H7 strain 2159 |
Toxin (Protein)
Gene name | hokW | Uniprot ID | A0A1Q4PF16 |
Locus tag | A4C45_RS13360 | Protein ID | WP_000813258.1 |
Coordinates | 2566913..2567068 (+) | Length | 52 a.a. |
Antitoxin (RNA)
Gene name | sokW | ||
Locus tag | - | ||
Coordinates | 2566843..2566901 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A4C45_RS13310 | 2561908..2562150 | + | 243 | WP_000747948.1 | hypothetical protein | - |
A4C45_RS13315 | 2562134..2562559 | + | 426 | WP_000693878.1 | Rha family transcriptional regulator | - |
A4C45_RS31015 | 2562628..2563671 | + | 1044 | WP_001262402.1 | hypothetical protein | - |
A4C45_RS31020 | 2563664..2564125 | + | 462 | WP_000139447.1 | replication protein | - |
A4C45_RS13330 | 2564159..2564875 | + | 717 | WP_000450627.1 | DUF1627 domain-containing protein | - |
A4C45_RS13335 | 2564908..2565189 | + | 282 | WP_000603384.1 | DNA-binding protein | - |
A4C45_RS13340 | 2565186..2565413 | + | 228 | WP_000699809.1 | hypothetical protein | - |
A4C45_RS13345 | 2565406..2565717 | + | 312 | WP_001289673.1 | hypothetical protein | - |
A4C45_RS13350 | 2565845..2566063 | + | 219 | WP_000683609.1 | DUF4014 family protein | - |
A4C45_RS13355 | 2566065..2566622 | + | 558 | WP_000104474.1 | DUF551 domain-containing protein | - |
- | 2566843..2566901 | - | 59 | - | - | Antitoxin |
A4C45_RS13360 | 2566913..2567068 | + | 156 | WP_000813258.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
A4C45_RS13365 | 2567188..2567532 | + | 345 | WP_000756596.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
A4C45_RS13370 | 2567654..2567926 | + | 273 | WP_000191872.1 | hypothetical protein | - |
A4C45_RS13375 | 2567928..2568977 | + | 1050 | WP_001265229.1 | DUF968 domain-containing protein | - |
A4C45_RS13380 | 2568990..2569295 | + | 306 | WP_001217444.1 | RusA family crossover junction endodeoxyribonuclease | - |
A4C45_RS13385 | 2569358..2569912 | + | 555 | WP_000640035.1 | DUF1133 family protein | - |
A4C45_RS31025 | 2570137..2570334 | + | 198 | WP_000917763.1 | hypothetical protein | - |
A4C45_RS13395 | 2570470..2571183 | + | 714 | WP_000301797.1 | helix-turn-helix domain-containing protein | - |
A4C45_RS13410 | 2571638..2572066 | + | 429 | WP_001303509.1 | tellurite resistance protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | nleG7' | 2506365..2605476 | 99111 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 52 a.a. Molecular weight: 5767.95 Da Isoelectric Point: 7.7942
>T66612 WP_000813258.1 NZ_CP017438:2566913-2567068 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK
Download Length: 156 bp
>T66612 NZ_CP017438:2566913-2567068 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA
Antitoxin
Download Length: 59 bp
>AT66612 NZ_CP017438:c2566901-2566843 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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