Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1945963..1946143 Replicon chromosome
Accession NZ_CP017090
Organism Staphylococcus aureus strain ISU935 isolate ST5

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag A2V17_RS14755 Protein ID WP_001801861.1
Coordinates 1945963..1946058 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1946086..1946143 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2V17_RS09760 1941126..1941776 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
A2V17_RS09765 1941857..1942852 + 996 WP_000070642.1 DUF4352 domain-containing protein -
A2V17_RS09770 1942927..1943553 + 627 WP_000669024.1 hypothetical protein -
A2V17_RS09775 1943594..1943935 + 342 WP_000627540.1 DUF3969 family protein -
A2V17_RS09780 1944036..1944608 + 573 WP_000414216.1 hypothetical protein -
A2V17_RS09785 1944806..1945818 - 1013 Protein_1857 IS3 family transposase -
A2V17_RS14755 1945963..1946058 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1946086..1946143 - 58 - - Antitoxin
A2V17_RS09790 1946181..1946282 + 102 WP_001792025.1 hypothetical protein -
A2V17_RS14760 1946260..1946421 - 162 Protein_1860 transposase -
A2V17_RS09795 1946412..1946906 - 495 Protein_1861 transposase -
A2V17_RS09800 1947358..1948587 - 1230 WP_000072627.1 restriction endonuclease subunit S -
A2V17_RS09805 1948580..1950136 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
A2V17_RS09810 1950300..1950434 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1941162..1981942 40780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T65915 WP_001801861.1 NZ_CP017090:1945963-1946058 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T65915 NZ_CP017090:1945963-1946058 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT65915 NZ_CP017090:c1946143-1946086 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References