Detailed information of TA system TA064237

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2750943..2751157
• Replicon: chromosome
• Accession: NZ_CP016106
• Organism: Clostridioides difficile strain DSM 29637

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: CDIF29637_RS13165
• Protein ID: WP_003429855.1
• Coordinates: 2750996..2751157 (-)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	2750943..2751076 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF29637_RS13145	2747142..2747300	-	159	WP_021401161.1	hypothetical protein	-
CDIF29637_RS13150	2747362..2748168	-	807	WP_021401148.1	hypothetical protein	-
CDIF29637_RS13155	2748294..2748464	-	171	WP_021361718.1	ribbon-helix-helix domain-containing protein	-
CDIF29637_RS13160	2748767..2749477	-	711	WP_079747220.1	SHOCT domain-containing protein	-
-	2750493..2750598	+	106	NuclAT_3	-	-
-	2750493..2750598	+	106	NuclAT_4	-	-
-	2750943..2751076	+	134	NuclAT_0	-	Antitoxin
-	2750943..2751076	+	134	NuclAT_1	-	Antitoxin
CDIF29637_RS13165	2750996..2751157	-	162	WP_003429855.1	hypothetical protein	Toxin
CDIF29637_RS13175	2751498..2751938	-	441	WP_003429853.1	phage portal protein	-
CDIF29637_RS13180	2752010..2752480	-	471	WP_003429851.1	phage tail tube protein	-
CDIF29637_RS13185	2752497..2753807	-	1311	WP_021363494.1	phage tail sheath family protein	-
CDIF29637_RS13190	2753808..2753984	-	177	WP_016728451.1	hypothetical protein	-
CDIF29637_RS13195	2753977..2754414	-	438	WP_021401575.1	hypothetical protein	-
CDIF29637_RS13200	2754407..2754832	-	426	WP_021401245.1	HK97 gp10 family phage protein	-
CDIF29637_RS13205	2754832..2755194	-	363	WP_021401269.1	hypothetical protein	-
CDIF29637_RS13210	2755188..2755589	-	402	WP_021401267.1	hypothetical protein	-
CDIF29637_RS13215	2755599..2755832	-	234	WP_009896624.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2725214..2782831	57617

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T64237 WP_003429855.1 NZ_CP016106:c2751157-2750996 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T64237 NZ_CP016106:c2751157-2750996 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin

Nucleotide

• Length: 134 bp

>AT64237 NZ_CP016106:2750943-2751076 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin