Detailed information of TA system TA064234

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2484455..2484657
• Replicon: chromosome
• Accession: NZ_CP016106
• Organism: Clostridioides difficile strain DSM 29637

Toxin (Protein)

• Gene name: CD2299.1
• Uniprot ID: -
• Locus tag: CDIF29637_RS11905
• Protein ID: WP_021425031.1
• Coordinates: 2484505..2484657 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ1641
Locus tag	-
Coordinates	2484455..2484584 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF29637_RS11875	2480421..2480885	+	465	WP_021401486.1	hypothetical protein	-
CDIF29637_RS11885	2481209..2481370	-	162	WP_004454578.1	hypothetical protein	-
CDIF29637_RS19310	2481422..2482235	-	814	Protein_2198	toxin Bro	-
CDIF29637_RS19315	2482356..2482508	-	153	WP_021401405.1	hypothetical protein	-
CDIF29637_RS11900	2483389..2484311	-	923	Protein_2200	SHOCT domain-containing protein	-
-	2484455..2484584	+	130	NuclAT_2	-	Antitoxin
CDIF29637_RS11905	2484505..2484657	-	153	WP_021425031.1	hypothetical protein	Toxin
CDIF29637_RS11910	2484931..2485254	-	324	WP_009897482.1	hypothetical protein	-
CDIF29637_RS11915	2485290..2485544	-	255	WP_118701627.1	hypothetical protein	-
CDIF29637_RS11920	2485852..2486361	-	510	Protein_2204	transposase	-
CDIF29637_RS11925	2486639..2487013	-	375	Protein_2205	BlaI/MecI/CopY family transcriptional regulator	-
CDIF29637_RS11930	2487118..2487492	-	375	WP_004454597.1	BlaI/MecI/CopY family transcriptional regulator	-
CDIF29637_RS11935	2488296..2488784	+	489	WP_004454599.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
CDIF29637_RS11940	2489173..2489343	+	171	WP_004454601.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2476834..2494591	17757

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5787.89 Da
• Isoelectric Point: 10.6365

>T64234 WP_021425031.1 NZ_CP016106:c2484657-2484505 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSAAKSDLKIDINFKYHRKK

Nucleotide

• Length: 153 bp

>T64234 NZ_CP016106:c2484657-2484505 [Clostridioides difficile]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGTAAGTTAATCAAAAA
AGTAAAAAGCCACTCTGCCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA

Antitoxin

Nucleotide

• Length: 130 bp

>AT64234 NZ_CP016106:2484455-2484584 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGCAGAGTGGCTTTTTACTTTTTTGA

Structures

Antitoxin