Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2778616..2778825 Replicon chromosome
Accession NZ_CP016104
Organism Clostridioides difficile strain DSM 29629

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF29629_RS13195 Protein ID WP_004454815.1
Coordinates 2778667..2778825 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2778616..2778750 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29629_RS13180 2773723..2775351 + 1629 WP_022617147.1 aspartate 4-decarboxylase -
CDIF29629_RS13185 2775472..2776467 + 996 WP_003431031.1 asparaginase -
CDIF29629_RS13190 2776652..2777035 - 384 WP_070116827.1 BlaI/MecI/CopY family transcriptional regulator -
- 2778616..2778750 + 135 NuclAT_2 - Antitoxin
CDIF29629_RS13195 2778667..2778825 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF29629_RS13200 2779183..2780553 - 1371 WP_070116829.1 cell wall-binding protein Cwp29 -
CDIF29629_RS13205 2780835..2780933 + 99 Protein_2473 Arm DNA-binding domain-containing protein -
CDIF29629_RS13210 2780952..2781374 + 423 WP_003431042.1 hypothetical protein -
CDIF29629_RS13215 2781692..2781877 + 186 WP_107615967.1 tyrosine-type recombinase/integrase -
CDIF29629_RS13220 2782240..2782320 - 81 Protein_2476 VOC family protein -
CDIF29629_RS13225 2782360..2783028 - 669 WP_070116831.1 VanZ family protein -
CDIF29629_RS13230 2783127..2783510 - 384 WP_074048203.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T64227 WP_004454815.1 NZ_CP016104:c2778825-2778667 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T64227 NZ_CP016104:c2778825-2778667 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT64227 NZ_CP016104:2778616-2778750 [Clostridioides difficile]
AAGAAGAGCTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References