Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1346446..1346651 Replicon chromosome
Accession NZ_CP016104
Organism Clostridioides difficile strain DSM 29629

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag CDIF29629_RS06430 Protein ID WP_009896140.1
Coordinates 1346446..1346598 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1346578..1346651 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29629_RS06410 1341908..1342192 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
CDIF29629_RS06415 1342215..1343732 - 1518 WP_070117367.1 recombinase family protein -
CDIF29629_RS06420 1343857..1344678 - 822 WP_070117369.1 tetratricopeptide repeat protein -
CDIF29629_RS06425 1344869..1346296 + 1428 WP_070117371.1 cell wall-binding protein Cwp26 -
CDIF29629_RS06430 1346446..1346598 + 153 WP_009896140.1 hypothetical protein Toxin
- 1346578..1346651 - 74 NuclAT_8 - Antitoxin
CDIF29629_RS06435 1348109..1348332 - 224 Protein_1150 helix-turn-helix transcriptional regulator -
CDIF29629_RS06440 1349034..1349189 + 156 WP_038810520.1 hypothetical protein -
CDIF29629_RS06450 1349435..1349686 + 252 WP_074048076.1 hypothetical protein -
CDIF29629_RS06470 1350904..1351287 - 384 WP_070117374.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T64221 WP_009896140.1 NZ_CP016104:1346446-1346598 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T64221 NZ_CP016104:1346446-1346598 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT64221 NZ_CP016104:c1346651-1346578 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References