Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2547834..2548014 Replicon chromosome
Accession NZ_CP015173
Organism Staphylococcus aureus strain RIVM6519

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag A5J11_RS14830 Protein ID WP_001801861.1
Coordinates 2547834..2547929 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2547957..2548014 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5J11_RS12625 2542997..2543647 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
A5J11_RS12630 2543728..2544723 + 996 WP_000070642.1 DUF4352 domain-containing protein -
A5J11_RS12635 2544798..2545424 + 627 WP_000669024.1 hypothetical protein -
A5J11_RS12640 2545465..2545806 + 342 WP_000627540.1 DUF3969 family protein -
A5J11_RS12645 2545907..2546479 + 573 WP_000414216.1 hypothetical protein -
A5J11_RS14615 2546677..2547689 - 1013 Protein_2428 IS3 family transposase -
A5J11_RS14830 2547834..2547929 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2547957..2548014 - 58 - - Antitoxin
A5J11_RS12665 2548052..2548153 + 102 WP_001792025.1 hypothetical protein -
A5J11_RS14835 2548131..2548292 - 162 Protein_2431 transposase -
A5J11_RS12670 2548283..2548777 - 495 Protein_2432 transposase -
A5J11_RS12675 2549229..2550458 - 1230 WP_000072627.1 restriction endonuclease subunit S -
A5J11_RS12680 2550451..2552007 - 1557 WP_031862851.1 type I restriction-modification system subunit M -
A5J11_RS12685 2552171..2552305 - 135 WP_063125024.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 2542239..2574847 32608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T62588 WP_001801861.1 NZ_CP015173:2547834-2547929 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T62588 NZ_CP015173:2547834-2547929 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT62588 NZ_CP015173:c2548014-2547957 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References