Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 5467304..5467675 Replicon chromosome
Accession NZ_CP015023
Organism Escherichia coli strain SRCC 1675

Toxin (Protein)


Gene name ralR Uniprot ID A0A0D6ZRD3
Locus tag AR439_RS28495 Protein ID WP_001443846.1
Coordinates 5467526..5467675 (-) Length 50 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 5467304..5467482 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR439_RS33495 5463056..5463226 + 171 WP_001625136.1 hypothetical protein -
AR439_RS28470 5463259..5464632 + 1374 WP_000123746.1 ATP-dependent RNA helicase DbpA -
AR439_RS28475 5464761..5465696 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
AR439_RS31235 5465748..5466983 - 1236 WP_000040839.1 site-specific integrase -
AR439_RS28485 5466985..5467200 - 216 WP_000079604.1 excisionase XisR -
AR439_RS28490 5467300..5467488 - 189 WP_001302840.1 DUF1187 family protein -
- 5467304..5467482 + 179 NuclAT_0 - Antitoxin
- 5467304..5467482 + 179 NuclAT_0 - Antitoxin
- 5467304..5467482 + 179 NuclAT_0 - Antitoxin
- 5467304..5467482 + 179 NuclAT_0 - Antitoxin
AR439_RS28495 5467526..5467675 - 150 WP_001443846.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
AR439_RS28500 5467731..5468540 - 810 WP_000166313.1 recombination protein RecT -
AR439_RS28505 5468533..5471133 - 2601 WP_000105140.1 exodeoxyribonuclease VIII -
AR439_RS28510 5471235..5471510 - 276 WP_001344816.1 hypothetical protein -
AR439_RS28515 5471585..5471755 - 171 WP_001352098.1 conserved protein, Rac prophage -
AR439_RS28520 5471755..5471976 - 222 WP_000560223.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 5465748..5506575 40827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-48)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5383.12 Da        Isoelectric Point: 8.3398

>T62105 WP_001443846.1 NZ_CP015023:c5467675-5467526 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Download         Length: 150 bp

>T62105 NZ_CP015023:c5467675-5467526 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin


Download         Length: 179 bp

>AT62105 NZ_CP015023:5467304-5467482 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6ZRD3

Antitoxin

Download structure file

References