Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1972220..1972402 Replicon chromosome
Accession NZ_CP014438
Organism Staphylococcus aureus strain USA300-SUR22

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag AYM35_RS15725 Protein ID WP_001801861.1
Coordinates 1972220..1972315 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1972343..1972402 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM35_RS10130 1967880..1968506 + 627 Protein_1903 hypothetical protein -
AYM35_RS10135 1968547..1968891 + 345 WP_000627551.1 DUF3969 family protein -
AYM35_RS10140 1968989..1969540 + 552 WP_000414205.1 hypothetical protein -
AYM35_RS10145 1969758..1970399 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
AYM35_RS10150 1970513..1970698 - 186 WP_000809857.1 hypothetical protein -
AYM35_RS10155 1970700..1970876 - 177 WP_000375476.1 hypothetical protein -
AYM35_RS10160 1970887..1971270 - 384 WP_000070811.1 hypothetical protein -
AYM35_RS10170 1971874..1972017 - 144 WP_001549059.1 transposase -
AYM35_RS15725 1972220..1972315 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1972343..1972402 - 60 - - Antitoxin
AYM35_RS10175 1972438..1972539 + 102 WP_001791893.1 hypothetical protein -
AYM35_RS10180 1972517..1972693 - 177 Protein_1913 transposase -
AYM35_RS10185 1972887..1973264 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1965320..2005491 40171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T61178 WP_001801861.1 NZ_CP014438:1972220-1972315 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T61178 NZ_CP014438:1972220-1972315 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT61178 NZ_CP014438:c1972402-1972343 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References