Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1933155..1933337 Replicon chromosome
Accession NZ_CP014407
Organism Staphylococcus aureus strain USA300-SUR12

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag AYM25_RS15410 Protein ID WP_001801861.1
Coordinates 1933155..1933250 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1933278..1933337 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM25_RS09830 1928815..1929441 + 627 Protein_1845 hypothetical protein -
AYM25_RS09835 1929482..1929826 + 345 WP_077444006.1 DUF3969 family protein -
AYM25_RS09840 1929924..1930475 + 552 WP_000414205.1 hypothetical protein -
AYM25_RS09845 1930693..1931334 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
AYM25_RS09850 1931448..1931633 - 186 WP_000809857.1 hypothetical protein -
AYM25_RS09855 1931635..1931811 - 177 WP_000375476.1 hypothetical protein -
AYM25_RS09860 1931822..1932205 - 384 WP_000070811.1 hypothetical protein -
AYM25_RS09870 1932809..1932952 - 144 WP_001549059.1 transposase -
AYM25_RS15410 1933155..1933250 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1933278..1933337 - 60 - - Antitoxin
AYM25_RS09875 1933373..1933474 + 102 WP_001791893.1 hypothetical protein -
AYM25_RS09880 1933452..1933628 - 177 Protein_1855 transposase -
AYM25_RS09885 1933822..1934199 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1926255..1966426 40171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T61000 WP_001801861.1 NZ_CP014407:1933155-1933250 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T61000 NZ_CP014407:1933155-1933250 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT61000 NZ_CP014407:c1933337-1933278 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References