Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | ralRA/- |
Location | 2127579..2127950 | Replicon | chromosome |
Accession | NZ_CP014268 | ||
Organism | Escherichia coli B strain C2566 |
Toxin (Protein)
Gene name | ralR | Uniprot ID | F4VC37 |
Locus tag | C2566_RS10615 | Protein ID | WP_001317028.1 |
Coordinates | 2127756..2127950 (-) | Length | 65 a.a. |
Antitoxin (RNA)
Gene name | ralA | ||
Locus tag | - | ||
Coordinates | 2127579..2127757 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C2566_RS10590 | 2123534..2124907 | + | 1374 | WP_000123737.1 | ATP-dependent RNA helicase DbpA | - |
C2566_RS10595 | 2125036..2125971 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
C2566_RS23025 | 2126023..2127258 | - | 1236 | WP_000040858.1 | site-specific integrase | - |
C2566_RS10605 | 2127260..2127475 | - | 216 | WP_000079604.1 | excisionase XisR | - |
C2566_RS10610 | 2127554..2127763 | - | 210 | WP_000276809.1 | double-strand break reduction protein RcbA | - |
- | 2127579..2127757 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2127579..2127757 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2127579..2127757 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2127579..2127757 | + | 179 | NuclAT_0 | - | Antitoxin |
C2566_RS10615 | 2127756..2127950 | - | 195 | WP_001317028.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
C2566_RS10620 | 2128007..2128816 | - | 810 | WP_000166319.1 | recombination protein RecT | - |
C2566_RS10625 | 2128809..2129908 | - | 1100 | Protein_2010 | PD-(D/E)XK nuclease-like domain-containing protein | - |
C2566_RS10630 | 2130010..2130285 | - | 276 | WP_000632297.1 | protein RacC | - |
C2566_RS10635 | 2130360..2130530 | - | 171 | WP_001352098.1 | conserved protein, Rac prophage | - |
C2566_RS10640 | 2130530..2130751 | - | 222 | WP_000560223.1 | killing protein KilR | - |
C2566_RS10645 | 2131193..2131681 | + | 489 | WP_001312793.1 | superinfection exclusion protein B | - |
C2566_RS10650 | 2131678..2131833 | - | 156 | WP_001169151.1 | YdaF family protein | - |
C2566_RS10655 | 2131977..2132189 | + | 213 | WP_012775985.1 | phage lysis protein EssD | - |
C2566_RS10660 | 2132194..2132538 | + | 345 | WP_000193293.1 | YdfR family protein | - |
C2566_RS10665 | 2132504..2132776 | - | 273 | WP_000370546.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2126023..2138088 | 12065 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7018.89 Da Isoelectric Point: 8.9538
>T60467 WP_001317028.1 NZ_CP014268:c2127950-2127756 [Escherichia coli B]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T60467 NZ_CP014268:c2127950-2127756 [Escherichia coli B]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 179 bp
>AT60467 NZ_CP014268:2127579-2127757 [Escherichia coli B]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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