Detailed information of TA system TA060102

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 4802317..4802545
• Replicon: chromosome
• Accession: NZ_CP014070
• Organism: Citrobacter amalonaticus strain FDAARGOS_165

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: AL524_RS49120
• Protein ID: WP_061070584.1
• Coordinates: 4802317..4802544 (-)
• Length: 76 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4802327..4802545 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL524_RS49115	4801946..4802266	+	321	WP_061070583.1	hypothetical protein	-
AL524_RS49120	4802317..4802544	-	228	WP_061070584.1	SymE family type I addiction module toxin	Toxin
-	4802327..4802545	+	219	-	-	Antitoxin
AL524_RS49125	4802547..4803405	-	859	Protein_4442	IS3 family transposase	-
AL524_RS49130	4803573..4804112	-	540	WP_044255706.1	hypothetical protein	-
AL524_RS49135	4804462..4804964	+	503	Protein_4444	replication initiation protein	-
AL524_RS49140	4805544..4807403	-	1860	WP_054177121.1	bifunctional glutathionylspermidine amidase/synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-40)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8341.56 Da
• Isoelectric Point: 7.1630

>T60102 WP_061070584.1 NZ_CP014070:c4802544-4802317 [Citrobacter amalonaticus]
MTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRKELYQVKKSMKHIKAGVNNVVNGD

Nucleotide

• Length: 228 bp

>T60102 NZ_CP014070:c4802544-4802317 [Citrobacter amalonaticus]
ATGACCACCTATTACTCACGCATTCCCAGTCTGCATCTCAAGGGTGACTGGCTGGCAGAAGCGGGATTTGATACCGGGGC
GAGCGTGACCGTGAAGATCTCCGAGGGGTGTTTGACTCTGATTGTGGAGACAGACGAAGTGAGAGATCTACGGAAGGAGC
TTTATCAGGTGAAAAAGTCGATGAAGCATATTAAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Nucleotide

• Length: 219 bp

>AT60102 NZ_CP014070:4802327-4802545 [Citrobacter amalonaticus]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCTCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCCTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCACCCTTGAGATGCAGACTGGGAATGCGTGAGTAATAGGTGGTCATG

Structures

Antitoxin