Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1953317..1953499 Replicon chromosome
Accession NZ_CP013957
Organism Staphylococcus aureus strain V521 isolate Sequencing

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag ASL17_RS17040 Protein ID WP_001801861.1
Coordinates 1953317..1953412 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1953440..1953499 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASL17_RS09670 1948977..1949603 + 627 WP_000669046.1 hypothetical protein -
ASL17_RS09675 1949644..1949988 + 345 WP_000627551.1 DUF3969 family protein -
ASL17_RS09680 1950086..1950637 + 552 WP_000414205.1 hypothetical protein -
ASL17_RS09685 1950855..1951496 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
ASL17_RS09690 1951610..1951795 - 186 WP_000809857.1 hypothetical protein -
ASL17_RS09695 1951797..1951973 - 177 WP_000375476.1 hypothetical protein -
ASL17_RS09700 1951984..1952367 - 384 WP_000070811.1 hypothetical protein -
ASL17_RS09710 1952971..1953114 - 144 WP_001549059.1 transposase -
ASL17_RS17040 1953317..1953412 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1953440..1953499 - 60 - - Antitoxin
ASL17_RS09715 1953535..1953636 + 102 WP_001791893.1 hypothetical protein -
ASL17_RS16605 1953614..1953790 - 177 Protein_1874 transposase -
ASL17_RS09720 1953984..1954361 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1946417..1985337 38920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T59711 WP_001801861.1 NZ_CP013957:1953317-1953412 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T59711 NZ_CP013957:1953317-1953412 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT59711 NZ_CP013957:c1953499-1953440 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References