Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 2167022..2167393 Replicon chromosome
Accession NZ_CP013031
Organism Escherichia coli strain H1827/12

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag AB847_RS10760 Protein ID WP_001317028.1
Coordinates 2167199..2167393 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 2167022..2167200 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB847_RS10735 2162977..2164350 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
AB847_RS10740 2164479..2165414 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
AB847_RS24365 2165466..2166701 - 1236 WP_000040858.1 site-specific integrase -
AB847_RS10750 2166703..2166918 - 216 WP_000079604.1 excisionase XisR -
AB847_RS10755 2166997..2167206 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 2167022..2167200 + 179 NuclAT_0 - Antitoxin
- 2167022..2167200 + 179 NuclAT_0 - Antitoxin
- 2167022..2167200 + 179 NuclAT_0 - Antitoxin
- 2167022..2167200 + 179 NuclAT_0 - Antitoxin
AB847_RS10760 2167199..2167393 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
AB847_RS10765 2167450..2168259 - 810 WP_000166319.1 recombination protein RecT -
AB847_RS10770 2168252..2170852 - 2601 WP_000105139.1 exodeoxyribonuclease VIII -
AB847_RS10775 2170954..2171229 - 276 WP_000632297.1 protein RacC -
AB847_RS10780 2171304..2171474 - 171 WP_001352098.1 conserved protein, Rac prophage -
AB847_RS10785 2171474..2171695 - 222 WP_032201602.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2165466..2181576 16110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T57798 WP_001317028.1 NZ_CP013031:c2167393-2167199 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T57798 NZ_CP013031:c2167393-2167199 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT57798 NZ_CP013031:2167022-2167200 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References