Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1852863..1853043 Replicon chromosome
Accession NZ_CP012593
Organism Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag IT770_RS08900 Protein ID WP_001801861.1
Coordinates 1852863..1852958 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1852986..1853043 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT770_RS08870 1848026..1848676 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
IT770_RS08875 1848757..1849752 + 996 WP_000070642.1 DUF4352 domain-containing protein -
IT770_RS08880 1849827..1850453 + 627 WP_000669024.1 hypothetical protein -
IT770_RS08885 1850494..1850835 + 342 WP_000627540.1 DUF3969 family protein -
IT770_RS08890 1850936..1851508 + 573 WP_000414216.1 hypothetical protein -
IT770_RS08895 1851706..1852718 - 1013 Protein_1749 IS3 family transposase -
IT770_RS08900 1852863..1852958 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1852986..1853043 - 58 - - Antitoxin
IT770_RS08905 1853081..1853182 + 102 WP_001792025.1 hypothetical protein -
IT770_RS08910 1853160..1853321 - 162 Protein_1752 transposase -
IT770_RS08915 1853312..1853806 - 495 Protein_1753 transposase -
IT770_RS08920 1854258..1855487 - 1230 WP_000072627.1 restriction endonuclease subunit S -
IT770_RS08925 1855480..1857036 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
IT770_RS08930 1857200..1857334 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1847268..1879876 32608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T56763 WP_001801861.1 NZ_CP012593:1852863-1852958 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T56763 NZ_CP012593:1852863-1852958 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT56763 NZ_CP012593:c1853043-1852986 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References