Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2247445..2247641 Replicon chromosome
Accession NZ_CP012325
Organism Clostridioides difficile strain DSM 29020

Toxin (Protein)


Gene name CD1418.2 Uniprot ID D5Q3X5
Locus tag CDIF29020_RS11060 Protein ID WP_003424190.1
Coordinates 2247489..2247641 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 2247445..2247545 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29020_RS11045 2242647..2242904 - 258 WP_003424182.1 hypothetical protein -
CDIF29020_RS11050 2242891..2243124 - 234 WP_003424184.1 hypothetical protein -
CDIF29020_RS11055 2243312..2243500 + 189 WP_003424185.1 helix-turn-helix transcriptional regulator -
- 2247445..2247545 + 101 NuclAT_0 - Antitoxin
CDIF29020_RS11060 2247489..2247641 - 153 WP_003424190.1 hypothetical protein Toxin
CDIF29020_RS11070 2248469..2249014 + 546 WP_077699404.1 site-specific integrase -
CDIF29020_RS11075 2249559..2250404 + 846 WP_003424194.1 DUF4878 domain-containing protein -
CDIF29020_RS11080 2250628..2250792 - 165 WP_003424195.1 hypothetical protein -
CDIF29020_RS11085 2251324..2251655 - 332 Protein_2017 carboxymuconolactone decarboxylase family protein -
CDIF29020_RS11090 2251915..2252556 - 642 WP_003424198.1 SdpI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / tet(40) - 2023382..2329461 306079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5744.78 Da        Isoelectric Point: 10.6276

>T56293 WP_003424190.1 NZ_CP012325:c2247641-2247489 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Download         Length: 153 bp

>T56293 NZ_CP012325:c2247641-2247489 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT56293 NZ_CP012325:2247445-2247545 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A449XCJ1

Antitoxin

Download structure file

References