Detailed information of TA system TA056290

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2764962..2765171
• Replicon: chromosome
• Accession: NZ_CP012323
• Organism: Clostridioides difficile strain DSM 28669

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: CDIF28669_RS13240
• Protein ID: WP_003431040.1
• Coordinates: 2765013..2765171 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	2764962..2765096 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF28669_RS13210	2760097..2760297	+	201	WP_003431034.1	cold-shock protein	-
CDIF28669_RS13215	2760728..2762065	+	1338	WP_003431035.1	ATP-binding protein	-
CDIF28669_RS13220	2762108..2762689	+	582	WP_003431036.1	accessory gene regulator B family protein	-
CDIF28669_RS13225	2762707..2762868	+	162	WP_003431037.1	cyclic lactone autoinducer peptide	-
CDIF28669_RS13230	2762890..2763687	-	798	WP_003431038.1	N-acetylmuramoyl-L-alanine amidase	-
CDIF28669_RS13235	2763684..2763944	-	261	WP_003431039.1	phage holin family protein	-
-	2764962..2765096	+	135	NuclAT_2	-	Antitoxin
CDIF28669_RS13240	2765013..2765171	-	159	WP_003431040.1	hypothetical protein	Toxin
CDIF28669_RS13245	2765529..2766899	-	1371	WP_070112518.1	cell wall-binding protein Cwp29	-
CDIF28669_RS13250	2767181..2767279	+	99	Protein_2486	Arm DNA-binding domain-containing protein	-
CDIF28669_RS13255	2767298..2767720	+	423	WP_070112516.1	hypothetical protein	-
CDIF28669_RS13260	2768010..2768222	+	213	WP_109298682.1	tyrosine-type recombinase/integrase	-
CDIF28669_RS13265	2768585..2768665	-	81	Protein_2489	VOC family protein	-
CDIF28669_RS13270	2768705..2769373	-	669	WP_070112514.1	VanZ family protein	-
CDIF28669_RS13275	2769472..2769855	-	384	WP_077723373.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5982.18 Da
• Isoelectric Point: 11.3102

>T56290 WP_003431040.1 NZ_CP012323:c2765171-2765013 [Clostridioides difficile]
MDNFLQGILASLSASLIVYVASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T56290 NZ_CP012323:c2765171-2765013 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATGTAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT56290 NZ_CP012323:2764962-2765096 [Clostridioides difficile]
AAGAAGAGCTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin