Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2776115..2776324 Replicon chromosome
Accession NZ_CP012321
Organism Clostridioides difficile strain DSM 28666

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF28666_RS13275 Protein ID WP_004454815.1
Coordinates 2776166..2776324 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2776115..2776249 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF28666_RS13260 2771555..2773183 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CDIF28666_RS13265 2773304..2774299 + 996 WP_003431031.1 asparaginase -
CDIF28666_RS13270 2774477..2774860 - 384 WP_011861577.1 BlaI/MecI/CopY family transcriptional regulator -
- 2776115..2776249 + 135 NuclAT_0 - Antitoxin
CDIF28666_RS13275 2776166..2776324 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF28666_RS13280 2776683..2778053 - 1371 WP_021371390.1 cell wall-binding protein Cwp29 -
CDIF28666_RS13285 2778267..2779385 + 1119 WP_011861579.1 site-specific integrase -
CDIF28666_RS13290 2779702..2780370 - 669 WP_011861580.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T56283 WP_004454815.1 NZ_CP012321:c2776324-2776166 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T56283 NZ_CP012321:c2776324-2776166 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT56283 NZ_CP012321:2776115-2776249 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References