Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1548390..1548586 Replicon chromosome
Accession NZ_CP012321
Organism Clostridioides difficile strain DSM 28666

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag CDIF28666_RS07535 Protein ID WP_009902496.1
Coordinates 1548390..1548542 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1548486..1548586 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF28666_RS07505 1543930..1544523 - 594 WP_003438546.1 DUF308 domain-containing protein -
CDIF28666_RS07510 1544630..1545058 + 429 WP_003429356.1 DMT family transporter -
CDIF28666_RS07515 1545125..1545793 + 669 WP_118701673.1 diphthine--ammonia ligase -
CDIF28666_RS07520 1545911..1547266 - 1356 WP_003438549.1 MATE family efflux transporter -
CDIF28666_RS07535 1548390..1548542 + 153 WP_009902496.1 hypothetical protein Toxin
- 1548486..1548586 - 101 NuclAT_2 - Antitoxin
CDIF28666_RS07540 1550435..1552168 - 1734 WP_009902497.1 diguanylate cyclase -
CDIF28666_RS07545 1552408..1553253 - 846 WP_009889222.1 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T56277 WP_009902496.1 NZ_CP012321:1548390-1548542 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T56277 NZ_CP012321:1548390-1548542 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGCGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT56277 NZ_CP012321:c1548586-1548486 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACATAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCGCTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References