Detailed information of TA system TA056267

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2868242..2868451
• Replicon: chromosome
• Accession: NZ_CP012312
• Organism: Clostridioides difficile strain DSM 28670

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: CDIF28670_RS14075
• Protein ID: WP_003431040.1
• Coordinates: 2868293..2868451 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	2868242..2868376 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF28670_RS14045	2863574..2863774	+	201	WP_003431034.1	cold-shock protein	-
CDIF28670_RS14050	2864205..2865542	+	1338	WP_003431035.1	ATP-binding protein	-
CDIF28670_RS14055	2865585..2866166	+	582	WP_003431036.1	accessory gene regulator B family protein	-
CDIF28670_RS14060	2866184..2866345	+	162	WP_003431037.1	cyclic lactone autoinducer peptide	-
CDIF28670_RS14065	2866367..2867164	-	798	WP_003431038.1	N-acetylmuramoyl-L-alanine amidase	-
CDIF28670_RS14070	2867161..2867421	-	261	WP_003431039.1	phage holin family protein	-
-	2868242..2868376	+	135	NuclAT_0	-	Antitoxin
CDIF28670_RS14075	2868293..2868451	-	159	WP_003431040.1	hypothetical protein	Toxin
CDIF28670_RS14080	2868809..2870179	-	1371	WP_118712721.1	cell wall-binding protein Cwp29	-
CDIF28670_RS14085	2870461..2870559	+	99	Protein_2659	Arm DNA-binding domain-containing protein	-
CDIF28670_RS14090	2870578..2871000	+	423	WP_003431042.1	hypothetical protein	-
CDIF28670_RS14100	2871271..2871960	-	690	WP_118712723.1	VanZ family protein	-
CDIF28670_RS14105	2872059..2872442	-	384	WP_074048203.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5982.18 Da
• Isoelectric Point: 11.3102

>T56267 WP_003431040.1 NZ_CP012312:c2868451-2868293 [Clostridioides difficile]
MDNFLQGILASLSASLIVYVASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T56267 NZ_CP012312:c2868451-2868293 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATGTAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT56267 NZ_CP012312:2868242-2868376 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin