Detailed information of TA system TA056263

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1752860..1753074
• Replicon: chromosome
• Accession: NZ_CP012312
• Organism: Clostridioides difficile strain DSM 28670

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: CDIF28670_RS08675
• Protein ID: WP_003429855.1
• Coordinates: 1752860..1753021 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1752941..1753074 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF28670_RS08625	1748200..1748433	+	234	WP_070113070.1	hypothetical protein	-
CDIF28670_RS08630	1748443..1748844	+	402	WP_021363493.1	hypothetical protein	-
CDIF28670_RS08635	1748838..1749185	+	348	WP_070113072.1	hypothetical protein	-
CDIF28670_RS08640	1749185..1749610	+	426	WP_038812299.1	HK97 gp10 family phage protein	-
CDIF28670_RS08645	1749603..1750040	+	438	WP_003433544.1	hypothetical protein	-
CDIF28670_RS08650	1750033..1750209	+	177	WP_070112848.1	hypothetical protein	-
CDIF28670_RS08655	1750210..1751520	+	1311	WP_070116964.1	phage tail sheath family protein	-
CDIF28670_RS08660	1751537..1752007	+	471	WP_003429851.1	phage tail tube protein	-
CDIF28670_RS08665	1752079..1752519	+	441	WP_003429853.1	phage portal protein	-
CDIF28670_RS08675	1752860..1753021	+	162	WP_003429855.1	hypothetical protein	Toxin
-	1752941..1753074	-	134	NuclAT_1	-	Antitoxin
-	1752941..1753074	-	134	NuclAT_2	-	Antitoxin
-	1753419..1753467	-	49	NuclAT_4	-	-
-	1753419..1753467	-	49	NuclAT_6	-	-
-	1754248..1754353	-	106	NuclAT_3	-	-
-	1754248..1754353	-	106	NuclAT_5	-	-
CDIF28670_RS08680	1755137..1756018	+	882	WP_118712360.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1721930..1786352	64422

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T56263 WP_003429855.1 NZ_CP012312:1752860-1753021 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T56263 NZ_CP012312:1752860-1753021 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin

Nucleotide

• Length: 134 bp

>AT56263 NZ_CP012312:c1753074-1752941 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin