Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2847738..2847947 Replicon chromosome
Accession NZ_CP012309
Organism Clostridioides difficile strain DSM 28668

Toxin (Protein)


Gene name CD2517.1 Uniprot ID -
Locus tag CDIF28668_RS13550 Protein ID WP_118822397.1
Coordinates 2847789..2847947 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2847738..2847872 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF28668_RS13535 2843564..2845192 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CDIF28668_RS13540 2845313..2846308 + 996 WP_003431031.1 asparaginase -
CDIF28668_RS13545 2846497..2846880 - 384 Protein_2530 BlaI/MecI/CopY family transcriptional regulator -
- 2847738..2847872 + 135 NuclAT_0 - Antitoxin
CDIF28668_RS13550 2847789..2847947 - 159 WP_118822397.1 hypothetical protein Toxin
CDIF28668_RS13555 2848306..2849676 - 1371 WP_021422488.1 cell wall-binding protein Cwp29 -
CDIF28668_RS13560 2849873..2850007 + 135 WP_077716265.1 Arm DNA-binding domain-containing protein -
CDIF28668_RS13565 2850388..2850917 + 530 Protein_2534 site-specific integrase -
CDIF28668_RS13570 2851224..2851892 - 669 WP_021379351.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6024.26 Da        Isoelectric Point: 11.3102

>T56260 WP_118822397.1 NZ_CP012309:c2847947-2847789 [Clostridioides difficile]
MDNFLQGILVSLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T56260 NZ_CP012309:c2847947-2847789 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGTAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT56260 NZ_CP012309:2847738-2847872 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References