Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2017139..2017321 Replicon chromosome
Accession NZ_CP012015
Organism Staphylococcus aureus strain Gv51

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag SAGV51_RS16370 Protein ID WP_001801861.1
Coordinates 2017139..2017234 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2017262..2017321 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAGV51_RS10100 2012799..2013425 + 627 WP_000669046.1 hypothetical protein -
SAGV51_RS10105 2013466..2013810 + 345 WP_000627551.1 DUF3969 family protein -
SAGV51_RS10110 2013908..2014459 + 552 WP_000414205.1 hypothetical protein -
SAGV51_RS10115 2014677..2015318 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
SAGV51_RS10120 2015432..2015617 - 186 WP_000809857.1 hypothetical protein -
SAGV51_RS10125 2015619..2015795 - 177 WP_000375476.1 hypothetical protein -
SAGV51_RS10130 2015806..2016189 - 384 WP_000070811.1 hypothetical protein -
SAGV51_RS10140 2016793..2016936 - 144 WP_001549059.1 transposase -
SAGV51_RS16370 2017139..2017234 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2017262..2017321 - 60 - - Antitoxin
SAGV51_RS10145 2017357..2017458 + 102 WP_001791893.1 hypothetical protein -
SAGV51_RS15940 2017436..2017612 - 177 Protein_1967 transposase -
SAGV51_RS10150 2017806..2018183 - 378 WP_001037045.1 DUF1433 domain-containing protein -
SAGV51_RS10155 2018704..2020029 - 1326 Protein_1969 ATP-binding protein -
SAGV51_RS10160 2020133..2021305 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 2010239..2050490 40251
- flank IS/Tn - - 2020133..2021305 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T55491 WP_001801861.1 NZ_CP012015:2017139-2017234 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T55491 NZ_CP012015:2017139-2017234 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT55491 NZ_CP012015:c2017321-2017262 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References