Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2068592..2068774 Replicon chromosome
Accession NZ_CP012011
Organism Staphylococcus aureus strain HC1340

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag SAHC1340_RS16770 Protein ID WP_001801861.1
Coordinates 2068592..2068687 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2068715..2068774 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHC1340_RS10470 2064252..2064878 + 627 WP_000669046.1 hypothetical protein -
SAHC1340_RS10475 2064919..2065263 + 345 WP_000627551.1 DUF3969 family protein -
SAHC1340_RS10480 2065361..2065912 + 552 WP_000414205.1 hypothetical protein -
SAHC1340_RS10485 2066130..2066771 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
SAHC1340_RS10490 2066885..2067070 - 186 WP_000809857.1 hypothetical protein -
SAHC1340_RS10495 2067072..2067248 - 177 WP_000375476.1 hypothetical protein -
SAHC1340_RS10500 2067259..2067642 - 384 WP_000070811.1 hypothetical protein -
SAHC1340_RS10510 2068246..2068389 - 144 WP_001549059.1 transposase -
SAHC1340_RS16770 2068592..2068687 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2068715..2068774 - 60 - - Antitoxin
SAHC1340_RS10515 2068810..2068911 + 102 WP_001791893.1 hypothetical protein -
SAHC1340_RS16320 2068889..2069065 - 177 Protein_2038 transposase -
SAHC1340_RS10520 2069259..2069636 - 378 WP_001037045.1 DUF1433 domain-containing protein -
SAHC1340_RS10525 2070140..2071312 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 2061692..2103274 41582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T55423 WP_001801861.1 NZ_CP012011:2068592-2068687 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T55423 NZ_CP012011:2068592-2068687 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT55423 NZ_CP012011:c2068774-2068715 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References