Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2765985..2766194 Replicon chromosome
Accession NZ_CP011968
Organism Clostridioides difficile ATCC 9689 = DSM 1296

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF1296T_RS13280 Protein ID WP_004454815.1
Coordinates 2766036..2766194 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2765985..2766119 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF1296T_RS13265 2761408..2763036 + 1629 WP_009897704.1 aspartate 4-decarboxylase -
CDIF1296T_RS13270 2763157..2764152 + 996 WP_003431031.1 asparaginase -
CDIF1296T_RS13275 2764341..2764724 - 384 Protein_2541 BlaI/MecI/CopY family transcriptional regulator -
- 2765985..2766119 + 135 NuclAT_0 - Antitoxin
CDIF1296T_RS13280 2766036..2766194 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF1296T_RS13285 2766553..2767923 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
CDIF1296T_RS13290 2768206..2768304 + 99 Protein_2544 site-specific integrase -
CDIF1296T_RS13295 2768323..2768744 + 422 Protein_2545 hypothetical protein -
CDIF1296T_RS13300 2768975..2769247 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
CDIF1296T_RS13305 2769610..2769690 - 81 Protein_2547 VOC family protein -
CDIF1296T_RS13310 2769730..2770398 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T55287 WP_004454815.1 NZ_CP011968:c2766194-2766036 [Clostridioides difficile ATCC 9689 = DSM 1296]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T55287 NZ_CP011968:c2766194-2766036 [Clostridioides difficile ATCC 9689 = DSM 1296]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT55287 NZ_CP011968:2765985-2766119 [Clostridioides difficile ATCC 9689 = DSM 1296]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References