Detailed information of TA system TA055280

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 296249..296463
• Replicon: chromosome
• Accession: NZ_CP011968
• Organism: Clostridioides difficile ATCC 9689 = DSM 1296

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: CDIF1296T_RS01835
• Protein ID: WP_003429855.1
• Coordinates: 296249..296410 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	296330..296463 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF1296T_RS01790	291861..292205	+	345	WP_018112728.1	phage head-tail connector protein	-
CDIF1296T_RS01795	292205..292567	+	363	WP_018112727.1	hypothetical protein	-
CDIF1296T_RS01800	292567..292992	+	426	WP_018112726.1	HK97 gp10 family phage protein	-
CDIF1296T_RS01805	292985..293422	+	438	WP_018112725.1	hypothetical protein	-
CDIF1296T_RS01810	293415..293591	+	177	WP_009896638.1	hypothetical protein	-
CDIF1296T_RS01815	293592..294902	+	1311	WP_009896640.1	phage tail sheath family protein	-
CDIF1296T_RS01820	294923..295399	+	477	WP_018112724.1	phage tail tube protein	-
CDIF1296T_RS01825	295468..295908	+	441	WP_018112723.1	phage portal protein	-
CDIF1296T_RS01830	295908..296102	+	195	WP_011861033.1	hypothetical protein	-
CDIF1296T_RS01835	296249..296410	+	162	WP_003429855.1	hypothetical protein	Toxin
-	296330..296463	-	134	NuclAT_1	-	Antitoxin
-	296330..296463	-	134	NuclAT_2	-	Antitoxin
-	296808..296913	-	106	NuclAT_4	-	-
-	296808..296913	-	106	NuclAT_5	-	-
CDIF1296T_RS01840	297735..297908	+	174	WP_018112722.1	hypothetical protein	-
CDIF1296T_RS01845	298032..298373	+	342	Protein_266	toxin Bro	-
CDIF1296T_RS01850	298464..298859	+	396	WP_074089574.1	hypothetical protein	-
CDIF1296T_RS01855	299210..299980	+	771	WP_018112719.1	SHOCT domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	254924..321644	66720

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T55280 WP_003429855.1 NZ_CP011968:296249-296410 [Clostridioides difficile ATCC 9689 = DSM 1296]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T55280 NZ_CP011968:296249-296410 [Clostridioides difficile ATCC 9689 = DSM 1296]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin

Nucleotide

• Length: 134 bp

>AT55280 NZ_CP011968:c296463-296330 [Clostridioides difficile ATCC 9689 = DSM 1296]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin