Detailed information of TA system TA055107

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3317195..3317415
• Replicon: chromosome
• Accession: NZ_CP011847
• Organism: Clostridioides difficile strain DSM 27639

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: A0A069AVC0
• Locus tag: CDIF27639_RS20235
• Protein ID: WP_009901465.1
• Coordinates: 3317254..3317415 (-)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	3317195..3317334 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF27639_RS15630	3312420..3313226	-	807	WP_021361719.1	hypothetical protein	-
CDIF27639_RS15635	3313352..3313522	-	171	WP_021361718.1	ribbon-helix-helix domain-containing protein	-
CDIF27639_RS20230	3314315..3314491	-	177	WP_021388791.1	hypothetical protein	-
CDIF27639_RS15640	3314546..3315412	-	867	WP_095908768.1	phage repressor protein	-
CDIF27639_RS15645	3315531..3315719	-	189	WP_003429858.1	hypothetical protein	-
-	3317195..3317334	+	140	NuclAT_5	-	Antitoxin
-	3317195..3317334	+	140	NuclAT_6	-	Antitoxin
CDIF27639_RS20235	3317254..3317415	-	162	WP_009901465.1	hypothetical protein	Toxin
CDIF27639_RS15655	3317736..3318176	-	441	WP_021362035.1	phage XkdN-like family protein	-
CDIF27639_RS15660	3318181..3318438	-	258	WP_021362036.1	hypothetical protein	-
CDIF27639_RS15665	3318492..3318962	-	471	WP_021362037.1	phage tail tube protein	-
CDIF27639_RS15670	3318987..3320297	-	1311	WP_021362038.1	phage tail sheath family protein	-
CDIF27639_RS15675	3320298..3320474	-	177	WP_009901506.1	hypothetical protein	-
CDIF27639_RS15680	3320467..3320904	-	438	WP_009901504.1	hypothetical protein	-
CDIF27639_RS15685	3320897..3321322	-	426	WP_021362039.1	HK97 gp10 family phage protein	-
CDIF27639_RS15690	3321322..3321669	-	348	WP_021362040.1	hypothetical protein	-
CDIF27639_RS15695	3321669..3322013	-	345	WP_021362041.1	phage head-tail connector protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3290882..3349186	58304

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6034.28 Da
• Isoelectric Point: 11.0253

>T55107 WP_009901465.1 NZ_CP011847:c3317415-3317254 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELGFKIKFRKFK

Nucleotide

• Length: 162 bp

>T55107 NZ_CP011847:c3317415-3317254 [Clostridioides difficile]
ATGGACAATTTTTTACTTAGTATATTAGCTAGCTTGATAGCTAGTTTAATTGGATATATCGTTTGTAGATGTATCAAAAA
CGTAAAAAGCCACTCTACTCGTGGCAAGAGTAAAAGTGGCTGGGAACTTGGTTTTAAAATAAAGTTCCGCAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT55107 NZ_CP011847:3317195-3317334 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAAATATAAATTATTTAAATTTGCGGAACTT
TATTTTAAAACCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVC0

Antitoxin