Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2786210..2786419 Replicon chromosome
Accession NZ_CP011847
Organism Clostridioides difficile strain DSM 27639

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF27639_RS13375 Protein ID WP_004454815.1
Coordinates 2786261..2786419 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2786210..2786344 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF27639_RS13360 2781637..2783265 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CDIF27639_RS13365 2783386..2784381 + 996 WP_003431031.1 asparaginase -
CDIF27639_RS13370 2784570..2784953 - 384 Protein_2483 BlaI/MecI/CopY family transcriptional regulator -
- 2786210..2786344 + 135 NuclAT_2 - Antitoxin
CDIF27639_RS13375 2786261..2786419 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF27639_RS13380 2786778..2788148 - 1371 WP_021381153.1 cell wall-binding protein Cwp29 -
CDIF27639_RS13385 2788365..2789472 + 1108 Protein_2486 site-specific integrase -
CDIF27639_RS13390 2789789..2790457 - 669 WP_021361938.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T55100 WP_004454815.1 NZ_CP011847:c2786419-2786261 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T55100 NZ_CP011847:c2786419-2786261 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT55100 NZ_CP011847:2786210-2786344 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References