Detailed information of TA system TA055090

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1714901..1715121
• Replicon: chromosome
• Accession: NZ_CP011846
• Organism: Clostridioides difficile strain DSM 27638

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: CDIF27638_RS08335
• Protein ID: WP_003429855.1
• Coordinates: 1714901..1715062 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1714982..1715121 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF27638_RS08300	1710758..1711195	+	438	WP_009888839.1	hypothetical protein	-
CDIF27638_RS08305	1711188..1711364	+	177	WP_009888840.1	hypothetical protein	-
CDIF27638_RS08310	1711365..1712675	+	1311	WP_009893136.1	phage tail sheath family protein	-
CDIF27638_RS08315	1712692..1713162	+	471	WP_009888842.1	phage tail tube protein	-
CDIF27638_RS08320	1713221..1714048	+	828	WP_009888843.1	hypothetical protein	-
CDIF27638_RS08325	1714120..1714560	+	441	WP_003429853.1	phage portal protein	-
CDIF27638_RS08335	1714901..1715062	+	162	WP_003429855.1	hypothetical protein	Toxin
-	1714982..1715121	-	140	NuclAT_1	-	Antitoxin
-	1714982..1715121	-	140	NuclAT_2	-	Antitoxin
-	1715466..1715514	-	49	NuclAT_4	-	-
-	1715466..1715514	-	49	NuclAT_5	-	-
CDIF27638_RS08340	1716399..1716587	+	189	WP_003429858.1	hypothetical protein	-
CDIF27638_RS08345	1716706..1717572	+	867	WP_009888845.1	hypothetical protein	-
CDIF27638_RS08355	1718437..1718964	+	528	WP_009888847.1	DUF4352 domain-containing protein	-
CDIF27638_RS08360	1719102..1719869	+	768	WP_009888848.1	DUF4428 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T55090 WP_003429855.1 NZ_CP011846:1714901-1715062 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T55090 NZ_CP011846:1714901-1715062 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT55090 NZ_CP011846:c1715121-1714982 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin