Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2892749..2892958 Replicon chromosome
Accession NZ_CP010905
Organism Clostridioides difficile 630

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF630_RS20580 Protein ID WP_004454815.1
Coordinates 2892800..2892958 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2892749..2892883 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF630_RS13885 2888319..2889947 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CDIF630_RS13890 2890068..2891063 + 996 WP_003431031.1 asparaginase -
CDIF630_RS13895 2891241..2891624 - 384 WP_011861577.1 BlaI/MecI/CopY family transcriptional regulator -
- 2892749..2892883 + 135 NuclAT_4 - Antitoxin
CDIF630_RS20580 2892800..2892958 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF630_RS13910 2893317..2894687 - 1371 WP_011861578.1 cell wall-binding protein Cwp29 -
CDIF630_RS13915 2894901..2896019 + 1119 WP_011861579.1 site-specific integrase -
CDIF630_RS13920 2896336..2897004 - 669 WP_011861580.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T53090 WP_004454815.1 NZ_CP010905:c2892958-2892800 [Clostridioides difficile 630]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T53090 NZ_CP010905:c2892958-2892800 [Clostridioides difficile 630]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT53090 NZ_CP010905:2892749-2892883 [Clostridioides difficile 630]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References