Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1823047..1823252 Replicon chromosome
Accession NZ_CP010888
Organism Clostridioides difficile strain 08ACD0030

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag TW87_RS08755 Protein ID WP_009896140.1
Coordinates 1823047..1823199 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1823179..1823252 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TW87_RS08735 1818987..1819271 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
TW87_RS08740 1819294..1820811 - 1518 WP_003438169.1 recombinase family protein -
TW87_RS08745 1820936..1821757 - 822 WP_003438170.1 tetratricopeptide repeat protein -
TW87_RS08750 1821948..1822975 + 1028 Protein_1616 cell wall-binding protein Cwp26 -
TW87_RS08755 1823047..1823199 + 153 WP_009896140.1 hypothetical protein Toxin
- 1823179..1823252 - 74 NuclAT_9 - Antitoxin
TW87_RS08760 1824893..1825117 - 225 WP_021367699.1 helix-turn-helix domain-containing protein -
TW87_RS08765 1825796..1825951 + 156 WP_021363414.1 hypothetical protein -
TW87_RS08770 1826197..1826448 + 252 WP_003419270.1 hypothetical protein -
TW87_RS08780 1827090..1827299 + 210 WP_009902373.1 hypothetical protein -
TW87_RS08785 1827668..1828051 - 384 WP_003433385.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T53033 WP_009896140.1 NZ_CP010888:1823047-1823199 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T53033 NZ_CP010888:1823047-1823199 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT53033 NZ_CP010888:c1823252-1823179 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References