Detailed information of TA system TA053033

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1823047..1823252
• Replicon: chromosome
• Accession: NZ_CP010888
• Organism: Clostridioides difficile strain 08ACD0030

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: A0A069A9H6
• Locus tag: TW87_RS08755
• Protein ID: WP_009896140.1
• Coordinates: 1823047..1823199 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	1823179..1823252 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TW87_RS08735	1818987..1819271	-	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-
TW87_RS08740	1819294..1820811	-	1518	WP_003438169.1	recombinase family protein	-
TW87_RS08745	1820936..1821757	-	822	WP_003438170.1	tetratricopeptide repeat protein	-
TW87_RS08750	1821948..1822975	+	1028	Protein_1616	cell wall-binding protein Cwp26	-
TW87_RS08755	1823047..1823199	+	153	WP_009896140.1	hypothetical protein	Toxin
-	1823179..1823252	-	74	NuclAT_9	-	Antitoxin
TW87_RS08760	1824893..1825117	-	225	WP_021367699.1	helix-turn-helix domain-containing protein	-
TW87_RS08765	1825796..1825951	+	156	WP_021363414.1	hypothetical protein	-
TW87_RS08770	1826197..1826448	+	252	WP_003419270.1	hypothetical protein	-
TW87_RS08780	1827090..1827299	+	210	WP_009902373.1	hypothetical protein	-
TW87_RS08785	1827668..1828051	-	384	WP_003433385.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5811.96 Da
• Isoelectric Point: 11.1039

>T53033 WP_009896140.1 NZ_CP010888:1823047-1823199 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Nucleotide

• Length: 153 bp

>T53033 NZ_CP010888:1823047-1823199 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin

Nucleotide

• Length: 74 bp

>AT53033 NZ_CP010888:c1823252-1823179 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Structures

Toxin

• AlphaFold DB: A0A069A9H6

Antitoxin