Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1778742..1779283 Replicon chromosome
Accession NZ_CP009790
Organism Xylella fastidiosa strain U24d

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag XFUD_RS08585 Protein ID WP_031336866.1
Coordinates 1778742..1779065 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q9PCB8
Locus tag XFUD_RS08590 Protein ID WP_010894329.1
Coordinates 1779062..1779283 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFUD_RS08560 1775686..1776378 + 693 WP_031336589.1 7-cyano-7-deazaguanine synthase QueC -
XFUD_RS08570 1776513..1776884 - 372 Protein_1555 hypothetical protein -
XFUD_RS08575 1776988..1778166 + 1179 WP_010894325.1 replication initiation factor domain-containing protein -
XFUD_RS08580 1778153..1778485 + 333 WP_010894326.1 hypothetical protein -
XFUD_RS13485 1778498..1778653 + 156 WP_155114993.1 hypothetical protein -
XFUD_RS08585 1778742..1779065 - 324 WP_031336866.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
XFUD_RS08590 1779062..1779283 - 222 WP_010894329.1 antitoxin MazE family protein Antitoxin
XFUD_RS08595 1779569..1780003 - 435 WP_010894330.1 DUF3693 domain-containing protein -
XFUD_RS08600 1780144..1780446 + 303 WP_010894331.1 hypothetical protein -
XFUD_RS13490 1780433..1780747 + 315 WP_143704178.1 hypothetical protein -
XFUD_RS08605 1780751..1780933 + 183 WP_023906503.1 hypothetical protein -
XFUD_RS13495 1781062..1781241 - 180 WP_023907626.1 hypothetical protein -
XFUD_RS08615 1781501..1781929 + 429 Protein_1566 hypothetical protein -
XFUD_RS08620 1781933..1782600 + 668 Protein_1567 hypothetical protein -
XFUD_RS08625 1782593..1782877 + 285 WP_010894335.1 DUF2523 domain-containing protein -
XFUD_RS08630 1782877..1783947 + 1071 WP_010894336.1 zonular occludens toxin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1775287..1791435 16148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11771.81 Da        Isoelectric Point: 7.9848

>T49820 WP_031336866.1 NZ_CP009790:c1779065-1778742 [Xylella fastidiosa]
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVALCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDERMKAIERALLLIIGII

Download         Length: 324 bp

>T49820 NZ_CP009790:c1779065-1778742 [Xylella fastidiosa]
ATGATTCAACGTGGCGACCTTGTAACAGTTTCCCTACAAGGCGACTACGGCAAGCCTAGACCAGCGTTGATCGTTCAATC
AGACCTTCTAACGGAGTTAGATAGTGTCGCACTGTGTCCGGTCACGAGCGACCTGCGGAATGCGATATTTCGTGTCACCG
TTGAACCAACTGCGGCCAATGGTTTACGGACACTGTCGCAGGTCATGGTAGATAAAATTTCAACACTACCACGTAACAAA
ATCAGCGAACCTTTTGGACGTCTCAATGACGAGAGAATGAAAGCAATAGAAAGAGCATTGTTACTAATTATTGGTATCAT
TTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8426.53 Da        Isoelectric Point: 7.3606

>AT49820 WP_010894329.1 NZ_CP009790:c1779283-1779062 [Xylella fastidiosa]
MTSTHRPDSKIVHHREQMRAAGLRPVQLWVPDTRTPEFAAEIQSQCRALKGDQAEADALRFTEKAMTHIEDWK

Download         Length: 222 bp

>AT49820 NZ_CP009790:c1779283-1779062 [Xylella fastidiosa]
ATGACATCAACTCACAGACCAGACAGCAAGATAGTTCACCACAGGGAACAAATGCGCGCAGCTGGATTGCGTCCTGTGCA
GCTCTGGGTACCGGATACGCGCACACCGGAATTCGCTGCTGAAATTCAAAGCCAGTGCCGCGCCCTGAAAGGCGACCAGG
CAGAAGCCGACGCTTTACGCTTCACAGAAAAAGCCATGACCCATATTGAAGATTGGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9PCB8

References