Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1778757..1779298 Replicon chromosome
Accession NC_002488
Organism Xylella fastidiosa 9a5c

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag XF_RS08055 Protein ID WP_031336866.1
Coordinates 1778757..1779080 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q9PCB8
Locus tag XF_RS08060 Protein ID WP_010894329.1
Coordinates 1779077..1779298 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XF_RS08035 (XF1858) 1775701..1776393 + 693 WP_031336589.1 7-cyano-7-deazaguanine synthase QueC -
XF_RS13385 1776528..1776899 - 372 Protein_1575 hypothetical protein -
XF_RS08045 (XF1859) 1777003..1778181 + 1179 WP_010894325.1 replication initiation factor domain-containing protein -
XF_RS08050 (XF1860) 1778168..1778500 + 333 WP_010894326.1 hypothetical protein -
XF_RS14100 (XF1861) 1778513..1778668 + 156 WP_155114993.1 hypothetical protein -
XF_RS08055 (XF1862) 1778757..1779080 - 324 WP_031336866.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
XF_RS08060 (XF1863) 1779077..1779298 - 222 WP_010894329.1 antitoxin MazE family protein Antitoxin
XF_RS08065 (XF1864) 1779582..1780016 - 435 WP_010894330.1 DUF3693 domain-containing protein -
XF_RS08070 (XF1865) 1780157..1780459 + 303 WP_010894331.1 hypothetical protein -
XF_RS14105 1780446..1780760 + 315 WP_143704178.1 hypothetical protein -
XF_RS08075 (XF1866) 1780764..1780946 + 183 WP_023906503.1 hypothetical protein -
XF_RS13395 (XF1867) 1781514..1781942 + 429 Protein_1585 hypothetical protein -
XF_RS08085 (XF1868) 1781946..1782613 + 668 Protein_1586 hypothetical protein -
XF_RS08090 (XF1869) 1782606..1782890 + 285 WP_010894335.1 DUF2523 domain-containing protein -
XF_RS08095 (XF1870) 1782890..1783960 + 1071 WP_010894336.1 zonular occludens toxin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1775302..1791449 16147


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11771.81 Da        Isoelectric Point: 7.9848

>T20284 WP_031336866.1 NC_002488:c1779080-1778757 [Xylella fastidiosa 9a5c]
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVALCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDERMKAIERALLLIIGII

Download         Length: 324 bp

>T20284 NC_002488:c1779080-1778757 [Xylella fastidiosa 9a5c]
ATGATTCAACGTGGCGACCTTGTAACAGTTTCCCTACAAGGCGACTACGGCAAGCCTAGACCAGCGTTGATCGTTCAATC
AGACCTTCTAACGGAGTTAGATAGTGTCGCACTGTGTCCGGTCACGAGCGACCTGCGGAATGCGATATTTCGTGTCACCG
TTGAACCAACTGCGGCCAATGGTTTACGGACACTGTCGCAGGTCATGGTAGATAAAATTTCAACACTACCACGTAACAAA
ATCAGCGAACCTTTTGGACGTCTCAATGACGAGAGAATGAAAGCAATAGAAAGAGCATTGTTACTAATTATTGGTATCAT
TTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8426.53 Da        Isoelectric Point: 7.3606

>AT20284 WP_010894329.1 NC_002488:c1779298-1779077 [Xylella fastidiosa 9a5c]
MTSTHRPDSKIVHHREQMRAAGLRPVQLWVPDTRTPEFAAEIQSQCRALKGDQAEADALRFTEKAMTHIEDWK

Download         Length: 222 bp

>AT20284 NC_002488:c1779298-1779077 [Xylella fastidiosa 9a5c]
ATGACATCAACTCACAGACCAGACAGCAAGATAGTTCACCACAGGGAACAAATGCGCGCAGCTGGATTGCGTCCTGTGCA
GCTCTGGGTACCGGATACGCGCACACCGGAATTCGCTGCTGAAATTCAAAGCCAGTGCCGCGCCCTGAAAGGCGACCAGG
CAGAAGCCGACGCTTTACGCTTCACAGAAAAAGCCATGACCCATATTGAAGATTGGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9PCB8

References