46481

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2042431..2042611 Replicon chromosome
Accession NZ_CP007454
Organism Staphylococcus aureus strain 502A isolate RN6607

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag CH52_RS14925 Protein ID WP_001801861.1
Coordinates 2042516..2042611 (-) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2042431..2042488 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH52_RS10555 2038140..2038274 + 135 WP_001791797.1 hypothetical protein -
CH52_RS10560 2038438..2039994 + 1557 WP_000028669.1 type I restriction-modification system subunit M -
CH52_RS10565 2039987..2041216 + 1230 WP_000072627.1 restriction endonuclease subunit S -
CH52_RS10570 2041668..2042162 + 495 Protein_1991 transposase -
CH52_RS14920 2042153..2042314 + 162 Protein_1992 transposase -
CH52_RS10575 2042292..2042393 - 102 WP_001792025.1 hypothetical protein -
- 2042431..2042488 + 58 - - Antitoxin
CH52_RS14925 2042516..2042611 - 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
CH52_RS14705 2042756..2043768 + 1013 Protein_1995 IS3 family transposase -
CH52_RS10595 2043966..2044538 - 573 WP_000414216.1 hypothetical protein -
CH52_RS10600 2044639..2044980 - 342 WP_000627540.1 DUF3969 family protein -
CH52_RS10605 2045021..2045647 - 627 WP_000669024.1 hypothetical protein -
CH52_RS10610 2045722..2046717 - 996 WP_000070642.1 DUF4352 domain-containing protein -
CH52_RS10615 2046798..2047448 - 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - selk / hlgA / lukD 2015598..2048206 32608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T46481 WP_001801861.1 NZ_CP007454:c2042611-2042516 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T46481 NZ_CP007454:c2042611-2042516 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT46481 NZ_CP007454:2042431-2042488 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References