Detailed information of TA system TA042592

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3573198..3573586
• Replicon: chromosome
• Accession: NZ_AP026680
• Organism: Salmonella enterica subsp. enterica serovar Oranienburg strain 11548

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8UR93
• Locus tag: QMM99_RS17580
• Protein ID: WP_001632469.1
• Coordinates: 3573389..3573586 (+)
• Length: 66 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3573198..3573543 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMM99_RS17550	3569417..3570154	-	738	WP_023197143.1	pili assembly chaperone SafB	-
QMM99_RS17555	3570238..3570750	-	513	WP_077911100.1	pilus assembly protein	-
QMM99_RS17560	3571498..3572202	-	705	Protein_3434	integrase core domain-containing protein	-
QMM99_RS17565	3572255..3572569	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
QMM99_RS17570	3572636..3572914	-	279	WP_077463746.1	hypothetical protein	-
QMM99_RS17575	3572997..3573227	-	231	WP_223195471.1	RHS repeat-associated core domain-containing protein	-
-	3573198..3573543	-	346	-	-	Antitoxin
QMM99_RS17580	3573389..3573586	+	198	WP_001632469.1	type I addiction module toxin, SymE family	Toxin
QMM99_RS17585	3573658..3574083	-	426	WP_001805083.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3553029..3604229	51200

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7205.26 Da
• Isoelectric Point: 5.5830

>T42592 WP_001632469.1 NZ_AP026680:3573389-3573586 [Salmonella enterica subsp. enterica serovar Oranienburg]
MPTCYSQIPSGDWQEEVGFETGHGVTVKISQGCIVLMADSNEVQKLREQLYHAKQVVKGVKDVLV

Nucleotide

• Length: 198 bp

>T42592 NZ_AP026680:3573389-3573586 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGCCCACCTGTTACTCACAAATCCCCAGCGGCGACTGGCAGGAAGAAGTGGGATTTGAGACCGGGCACGGCGTCACCGT
GAAGATTTCACAGGGGTGTATTGTGCTGATGGCGGACAGTAACGAGGTGCAGAAGCTGCGCGAACAGCTTTATCATGCTA
AACAGGTGGTTAAGGGGGTGAAGGATGTGCTGGTTTAG

Antitoxin

Nucleotide

• Length: 346 bp

>AT42592 NZ_AP026680:c3573543-3573198 [Salmonella enterica subsp. enterica serovar Oranienburg]
TGATAAAGCTGTTCGCGCAGCTTCTGCACCTCGTTACTGTCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGT
GACGCCGTGCCCGGTCTCAAATCCCACTTCTTCCTGCCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGGCATGCAGG
CTTTGCTGTTGATGTGGCGGACGCTGACGCCGAGGCATCTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGT
GGAGCTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCAGCCCCGGCCAGTGATGA
GCAACCGGCTGCCGGGGCAGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8UR93

Antitoxin